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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Oct 1999 Volume 15 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Oct 1999 Volume 15 Issue 4

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Article

Balance between activated-STAT and MAP kinase regulates the growth of human bladder cell lines after treatment with epidermal growth factor.

  • Authors:
    • H Kawamata
    • K Hattori
    • F Omotehara
    • D Uchida
    • S Hino
    • M Sato
    • R Oyasu

  • View Affiliations / Copyright

    Affiliations: Second Department of Oral and Maxillofacial Surgery, Tokushima University School of Dentistry, Tokushima 770-8504, Japan.
  • Pages: 661-668
    |
    Published online on: October 1, 1999
       https://doi.org/10.3892/ijo.15.4.661
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Abstract

Epidermal growth factor (EGF) is a potent mitogen, and its action is mediated by MAP kinase (MAPK). Reportedly EGF activates STAT, induces the expression of p21waf1, and subsequently inhibits the growth of several types of cancer cells. In this study, we used human bladder cancer cells (T24 and RT4), immortalized non-tumorigenic human urothelial cells (1T-1, 1T-2, and 1T-3), and epidermal carcinoma cells (A431). EGF inhibited the growth of T24 and A431, and stimulated the growth of 1T-1, 1T-3 and 1T-2, but did not affect the growth of RT4. EGF activated MAPK strongly in 1T-1, and slightly in A431, T24, 1T-2, and 1T-3 but marginally in RT4. We detected the activation of STAT in T24, 1T-3 and A431 after EGF treatment. EGF enhanced the expression of p21waf1 mRNA in T24, 1T-2, 1T-3 and A431, and activated the p21waf1 promoter in T24 cells. These results suggest that i) EGF inhibits the growth of T24 cells via induction of p21waf1 mediated by STAT, and ii) the balance between the STAT-induced p21waf1 and MAPK activities regulates the growth of human bladder cells after EGF treatment.

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Copy and paste a formatted citation
Spandidos Publications style
Kawamata H, Hattori K, Omotehara F, Uchida D, Hino S, Sato M and Oyasu R: Balance between activated-STAT and MAP kinase regulates the growth of human bladder cell lines after treatment with epidermal growth factor.. Int J Oncol 15: 661-668, 1999.
APA
Kawamata, H., Hattori, K., Omotehara, F., Uchida, D., Hino, S., Sato, M., & Oyasu, R. (1999). Balance between activated-STAT and MAP kinase regulates the growth of human bladder cell lines after treatment with epidermal growth factor.. International Journal of Oncology, 15, 661-668. https://doi.org/10.3892/ijo.15.4.661
MLA
Kawamata, H., Hattori, K., Omotehara, F., Uchida, D., Hino, S., Sato, M., Oyasu, R."Balance between activated-STAT and MAP kinase regulates the growth of human bladder cell lines after treatment with epidermal growth factor.". International Journal of Oncology 15.4 (1999): 661-668.
Chicago
Kawamata, H., Hattori, K., Omotehara, F., Uchida, D., Hino, S., Sato, M., Oyasu, R."Balance between activated-STAT and MAP kinase regulates the growth of human bladder cell lines after treatment with epidermal growth factor.". International Journal of Oncology 15, no. 4 (1999): 661-668. https://doi.org/10.3892/ijo.15.4.661
Copy and paste a formatted citation
x
Spandidos Publications style
Kawamata H, Hattori K, Omotehara F, Uchida D, Hino S, Sato M and Oyasu R: Balance between activated-STAT and MAP kinase regulates the growth of human bladder cell lines after treatment with epidermal growth factor.. Int J Oncol 15: 661-668, 1999.
APA
Kawamata, H., Hattori, K., Omotehara, F., Uchida, D., Hino, S., Sato, M., & Oyasu, R. (1999). Balance between activated-STAT and MAP kinase regulates the growth of human bladder cell lines after treatment with epidermal growth factor.. International Journal of Oncology, 15, 661-668. https://doi.org/10.3892/ijo.15.4.661
MLA
Kawamata, H., Hattori, K., Omotehara, F., Uchida, D., Hino, S., Sato, M., Oyasu, R."Balance between activated-STAT and MAP kinase regulates the growth of human bladder cell lines after treatment with epidermal growth factor.". International Journal of Oncology 15.4 (1999): 661-668.
Chicago
Kawamata, H., Hattori, K., Omotehara, F., Uchida, D., Hino, S., Sato, M., Oyasu, R."Balance between activated-STAT and MAP kinase regulates the growth of human bladder cell lines after treatment with epidermal growth factor.". International Journal of Oncology 15, no. 4 (1999): 661-668. https://doi.org/10.3892/ijo.15.4.661
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