Allelic instability as a predictor of survival in Egyptian breast cancer patients.

  • Authors:
    • A R Zekri
    • A A Bahnassi
    • B Bove
    • Y Huang
    • I H Russo
    • A Rogatko
    • S Shaarawy
    • O A Shawki
    • M R Hamza
    • S Omer
    • H M Khaled
    • J Russo
  • View Affiliations

  • Published online on: October 1, 1999     https://doi.org/10.3892/ijo.15.4.757
  • Pages: 757-824
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

This work was designed with the purpose of determining whether the presence of allelic imbalances (AI) such as microsatellite instability (MSI) and loss of heterozygosity (LOH) in chromosomes 2, 11, 13, and 17 in primary breast cancer could be used as prognostic indicators of patient survival. The DNA from breast cancers removed from 29 patients who were followed-up for up to five years was analyzed for MSI and LOH using a panel of 24 markers located at chromosome 2 (TPO, D2S131, D2S144, D2S171, D2S177, D2S119, D2S123, D2S147 and D2S136), chromosome 11 (C-RAS, Int-2, D11S940, D11S912), chromosome 13 (D13S289, D13S260, D13S267, D13S218, D13S263, D13S155, and D13S162), and chromosome 17 (D17S513, TP53, D17S855, and D17S785). The frequency of AI in the markers studied ranged from 30-55%, being highest for D11S912, D2S171, TP53 and D17S855. Univariate analysis showed association between overall survival rate and AI in 9 out of the 24 markers tested. Five of them were located at the area of the mismatch repair gene (MMR)-2 gene, two at 11p, one at 13q and one at 17p. Using multivariate analysis, it was observed that only pathological and clinical stage (defined as stage II or not) and AI at D2S171, D11S912, or D17STP53 generated significant predictive models for survival.

Related Articles

Journal Cover

Oct 1999
Volume 15 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Zekri A, Bahnassi A, Bove B, Huang Y, Russo I, Rogatko A, Shaarawy S, Shawki O, Hamza M, Omer S, Omer S, et al: Allelic instability as a predictor of survival in Egyptian breast cancer patients.. Int J Oncol 15: 757-824, 1999.
APA
Zekri, A., Bahnassi, A., Bove, B., Huang, Y., Russo, I., Rogatko, A. ... Russo, J. (1999). Allelic instability as a predictor of survival in Egyptian breast cancer patients.. International Journal of Oncology, 15, 757-824. https://doi.org/10.3892/ijo.15.4.757
MLA
Zekri, A., Bahnassi, A., Bove, B., Huang, Y., Russo, I., Rogatko, A., Shaarawy, S., Shawki, O., Hamza, M., Omer, S., Khaled, H., Russo, J."Allelic instability as a predictor of survival in Egyptian breast cancer patients.". International Journal of Oncology 15.4 (1999): 757-824.
Chicago
Zekri, A., Bahnassi, A., Bove, B., Huang, Y., Russo, I., Rogatko, A., Shaarawy, S., Shawki, O., Hamza, M., Omer, S., Khaled, H., Russo, J."Allelic instability as a predictor of survival in Egyptian breast cancer patients.". International Journal of Oncology 15, no. 4 (1999): 757-824. https://doi.org/10.3892/ijo.15.4.757