Peripheral blood cells from weight-losing cancer patients control the hepatic acute phase response by a primarily interleukin-6 dependent mechanism.

  • Authors:
    • M G O'Riordain
    • J S Falconer
    • J Maingay
    • K C Fearon
    • J A Ross
  • View Affiliations

  • Published online on: October 1, 1999     https://doi.org/10.3892/ijo.15.4.823
  • Pages: 823-830
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Abstract

Cancer cachexia is associated with an elevated hepatic acute phase protein response, poor outcome and elevated cytokine production from peripheral blood mononuclear cells (PBMC). This study investigates the mechanism by which PBMC can induce a hepatic acute phase response. Supernatants from the peripheral blood cells of cancer patients induced significantly higher C-reactive protein (CRP) from hepatocytes (198+/-21 ng ml-1) than did supernatants from healthy controls (64+/-20, p<0.005). CRP production in vitro correlated with IL-6 production by PBMC from patients with pancreatic cancer (r=0.76, p<0.0001). This C-reactive protein production was reduced by 84% using neutralising antibody to IL-6 (p<0.001). There was a significant negative correlation between PBMC-induced hepatocyte C-reactive protein production and survival (r=-0.45, p<0.01). PBMC from cancer patients induce the hepatic acute phase response via a primarily IL-6-dependent mechanism.

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Oct 1999
Volume 15 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
O'Riordain M, Falconer J, Maingay J, Fearon K and Ross J: Peripheral blood cells from weight-losing cancer patients control the hepatic acute phase response by a primarily interleukin-6 dependent mechanism.. Int J Oncol 15: 823-830, 1999.
APA
O'Riordain, M., Falconer, J., Maingay, J., Fearon, K., & Ross, J. (1999). Peripheral blood cells from weight-losing cancer patients control the hepatic acute phase response by a primarily interleukin-6 dependent mechanism.. International Journal of Oncology, 15, 823-830. https://doi.org/10.3892/ijo.15.4.823
MLA
O'Riordain, M., Falconer, J., Maingay, J., Fearon, K., Ross, J."Peripheral blood cells from weight-losing cancer patients control the hepatic acute phase response by a primarily interleukin-6 dependent mechanism.". International Journal of Oncology 15.4 (1999): 823-830.
Chicago
O'Riordain, M., Falconer, J., Maingay, J., Fearon, K., Ross, J."Peripheral blood cells from weight-losing cancer patients control the hepatic acute phase response by a primarily interleukin-6 dependent mechanism.". International Journal of Oncology 15, no. 4 (1999): 823-830. https://doi.org/10.3892/ijo.15.4.823