search button

In vitro antitumour activity and cellular pharmacological properties of the platinum-iminoether complex trans-[PtCl2[E-HN=C(OMe)Me]2].

  • Authors:
    • M Coluccia
    • A Nassi
    • A Boccarelli
    • D Giordano
    • N Cardellicchio
    • F P Intini
    • G Natile
    • A Barletta
    • A Paradiso

  • View Affiliations

  • Published online on: November 1, 1999     https://doi.org/10.3892/ijo.15.5.1039
  • Pages: 1039-1083
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The platinum complex trans-[PtCl2¿E-HN=C(OMe)Me¿2] was compared to cisplatin for cytotoxicity towards tumour cells, and for cellular pharmacological properties in A2780 and cisplatin-resistant A2780/Cp8 ovarian cancer cells. Trans-[PtCl2¿E-HN=C(OMe)Me¿2] was comparably cytotoxic to cisplatin (mean IC50 after 72 h exposure = 6. 1 microM and 7 microM, respectively) and did not show cross-resistance in A2780/Cp8 cells (resistance factor = 0.9). Cellular accumulation measurements after treatment with equimolar drug concentrations showed that trans-[PtCl2¿E-HN=C(OMe)Me¿2] entered both A2780 and A2780/Cp8 cells much more efficiently than cisplatin, whose accumulation was reduced in A2780/Cp8 cells. Unlike cisplatin, trans-[PtCl2¿E-HN=C(OMe)Me¿2] induced rapidly cell death and cell cycle modifications of treated cells, thus indicating substantially different mechanistic properties.

Related Articles

Journal Cover

Nov 1999
Volume 15 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 5.2
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 11.4
  • CiteScore Rank: Q1: #40/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 1.125
  • SCImago Journal Rank (SJR): 1.105
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Coluccia M, Nassi A, Boccarelli A, Giordano D, Cardellicchio N, Intini F, Natile G, Barletta A and Paradiso A: In vitro antitumour activity and cellular pharmacological properties of the platinum-iminoether complex trans-[PtCl2[E-HN=C(OMe)Me]2].. Int J Oncol 15: 1039-1083, 1999
APA
Coluccia, M., Nassi, A., Boccarelli, A., Giordano, D., Cardellicchio, N., Intini, F. ... Paradiso, A. (1999). In vitro antitumour activity and cellular pharmacological properties of the platinum-iminoether complex trans-[PtCl2[E-HN=C(OMe)Me]2].. International Journal of Oncology, 15, 1039-1083. https://doi.org/10.3892/ijo.15.5.1039
MLA
Coluccia, M., Nassi, A., Boccarelli, A., Giordano, D., Cardellicchio, N., Intini, F., Natile, G., Barletta, A., Paradiso, A."In vitro antitumour activity and cellular pharmacological properties of the platinum-iminoether complex trans-[PtCl2[E-HN=C(OMe)Me]2].". International Journal of Oncology 15.5 (1999): 1039-1083.
Chicago
Coluccia, M., Nassi, A., Boccarelli, A., Giordano, D., Cardellicchio, N., Intini, F., Natile, G., Barletta, A., Paradiso, A."In vitro antitumour activity and cellular pharmacological properties of the platinum-iminoether complex trans-[PtCl2[E-HN=C(OMe)Me]2].". International Journal of Oncology 15, no. 5 (1999): 1039-1083. https://doi.org/10.3892/ijo.15.5.1039