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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Nov 1999 Volume 15 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Nov 1999 Volume 15 Issue 5

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Article

Wild-type p53 gene transfer resulted in cell cycle arrest, but not apoptosis of newly established human malignant fibrous histiocytoma cell line.

  • Authors:
    • K Endo
    • T Sakatani
    • M Watanabe
    • H Yoshida
    • E Nanba
    • H Ito

  • View Affiliations / Copyright

    Affiliations: First Department of Pathology, Faculty of Medicine, Tottori University, Tottori 683-8503, Japan.
  • Pages: 935-977
    |
    Published online on: November 1, 1999
       https://doi.org/10.3892/ijo.15.5.935
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Abstract

We established a human malignant fibrous histiocytoma (MFH) cell line, MFH-ToE, from a tumor originally developed in the right thigh of a 78-year-old woman. The original tumor histologically consisted of histiocytic, fibroblastic and giant cells. The tumor cells showed immunoreactivity for vimentin and alpha-1-antichymotrypsin, and were positive for acid phosphatase and non-specific esterase, being compatible with MFH. Although the histology of the heterotransplanted tumor into nude mice was similar to that of the primary MFH, the population of giant cells gradually decreased along with the culture passages. Cytogenetic analysis revealed a highly aneuploid nature with varying numbers of chromosomes from 71 to 140. Chromosome 17 showed monosomy and exon 6 to 8 of p53 gene was not amplified by PCR, implying absence of p53 function. Adenovirus vector-mediated wild-type p53 gene was successfully transfected into the MFH-ToE, which showed up-regulation of P53 and P21, as well as gradual up-regulation of Bcl-2 protein. The transfection resulted in cell cycle arrest, but not apoptosis of the MFH-ToE cells. These results revealed unique properties of the MFH-ToE, which might be useful in further studies analyzing pathological and biological characteristics of MFH.

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Copy and paste a formatted citation
Spandidos Publications style
Endo K, Sakatani T, Watanabe M, Yoshida H, Nanba E and Ito H: Wild-type p53 gene transfer resulted in cell cycle arrest, but not apoptosis of newly established human malignant fibrous histiocytoma cell line.. Int J Oncol 15: 935-977, 1999.
APA
Endo, K., Sakatani, T., Watanabe, M., Yoshida, H., Nanba, E., & Ito, H. (1999). Wild-type p53 gene transfer resulted in cell cycle arrest, but not apoptosis of newly established human malignant fibrous histiocytoma cell line.. International Journal of Oncology, 15, 935-977. https://doi.org/10.3892/ijo.15.5.935
MLA
Endo, K., Sakatani, T., Watanabe, M., Yoshida, H., Nanba, E., Ito, H."Wild-type p53 gene transfer resulted in cell cycle arrest, but not apoptosis of newly established human malignant fibrous histiocytoma cell line.". International Journal of Oncology 15.5 (1999): 935-977.
Chicago
Endo, K., Sakatani, T., Watanabe, M., Yoshida, H., Nanba, E., Ito, H."Wild-type p53 gene transfer resulted in cell cycle arrest, but not apoptosis of newly established human malignant fibrous histiocytoma cell line.". International Journal of Oncology 15, no. 5 (1999): 935-977. https://doi.org/10.3892/ijo.15.5.935
Copy and paste a formatted citation
x
Spandidos Publications style
Endo K, Sakatani T, Watanabe M, Yoshida H, Nanba E and Ito H: Wild-type p53 gene transfer resulted in cell cycle arrest, but not apoptosis of newly established human malignant fibrous histiocytoma cell line.. Int J Oncol 15: 935-977, 1999.
APA
Endo, K., Sakatani, T., Watanabe, M., Yoshida, H., Nanba, E., & Ito, H. (1999). Wild-type p53 gene transfer resulted in cell cycle arrest, but not apoptosis of newly established human malignant fibrous histiocytoma cell line.. International Journal of Oncology, 15, 935-977. https://doi.org/10.3892/ijo.15.5.935
MLA
Endo, K., Sakatani, T., Watanabe, M., Yoshida, H., Nanba, E., Ito, H."Wild-type p53 gene transfer resulted in cell cycle arrest, but not apoptosis of newly established human malignant fibrous histiocytoma cell line.". International Journal of Oncology 15.5 (1999): 935-977.
Chicago
Endo, K., Sakatani, T., Watanabe, M., Yoshida, H., Nanba, E., Ito, H."Wild-type p53 gene transfer resulted in cell cycle arrest, but not apoptosis of newly established human malignant fibrous histiocytoma cell line.". International Journal of Oncology 15, no. 5 (1999): 935-977. https://doi.org/10.3892/ijo.15.5.935
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