TGF-beta1 and IGF-1 expression are differently regulated by serum in metastatic and non-metastatic human breast cancer cells.

Perlino,E; Tommasi,S; Moro,L; Bellizzi,A; Marra,E; Casavola,V; Reshkin,S J

doi:10.3892/ijo.16.1.155

TGF-beta1 and IGF-1 expression are differently regulated by serum in metastatic and non-metastatic human breast cancer cells.

Authors:
- E Perlino
- S Tommasi
- L Moro
- A Bellizzi
- E Marra
- V Casavola
- S J Reshkin
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Affiliations: Centro di Studio sui Mitocondri e Metabolismo Energetico, C.N.R., Bari, I-70126 Bari, Italy.
Published online on: January 1, 2000 https://doi.org/10.3892/ijo.16.1.155
Pages: 155-215

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Abstract

Transforming growth factor-beta (TGF-beta) exerts an inhibitory effect on epithelial cell proliferation while insulin-like growth factor-1 (IGF-1) is a positive regulator of proliferation and together they may participate in driving neoplastic progression. The regulation of TGF-beta1 and IGF-1 gene expression was analyzed in an in vitro model of an estrogen receptor positive (ER+), non-metastatic (MCF-7) and an (ER-), metastatic (MDA-MB-435) breast cancer cell line, respectively. Our results indicate a loss of the regulation of TGF-beta1 and the gain of the expression and upregulation of IGF-1 pathways during malignant progression. These data demonstrate that two factors, convergent on cell growth, can have divergent roles in the regulation of the expression of TGF-beta1.