A pilot study of the effects of short-term tamoxifen therapy on Ki-67 labelling index in women with primary breast cancer.

  • Authors:
    • R D Dardes
    • J Horiguchi
    • V C Jordan
  • View Affiliations

  • Published online on: January 1, 2000     https://doi.org/10.3892/ijo.16.1.25
  • Pages: 25-55
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Abstract

In this study we demonstrate the change in estrogen receptor (ER) level and cell proliferation in human breast cancer after a short-term tamoxifen therapy. Ten pre- and post-treatment breast tumor samples were examined immunohistochemically using ER and Ki-67 antibodies. Before tamoxifen treatment, six (60%) of ten patients were positive for ER. Tamoxifen increased the ER level in one patient and decreased the level in 4 patients. There was no significant change in ER level by tamoxifen therapy. On the other hand, Ki-67 labelling index (LI) significantly decreased after tamoxifen treatment. When Ki-67 LI was analyzed according to ER level, there was no difference between pre- and post-tamoxifen treatment in ER-negative patients, however, a significant decrease of Ki-67 LI by tamoxifen treatment was seen in ER-positive patients. Patients who showed down-regulation of ER expression tended to show a decrease of Ki-67 LI after tamoxifen therapy. In conclusion, short-term tamoxifen therapy decreased the proliferation of breast cancer, in ER-positive breast tumor samples.

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Jan 2000
Volume 16 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Dardes R, Horiguchi J and Jordan V: A pilot study of the effects of short-term tamoxifen therapy on Ki-67 labelling index in women with primary breast cancer.. Int J Oncol 16: 25-55, 2000
APA
Dardes, R., Horiguchi, J., & Jordan, V. (2000). A pilot study of the effects of short-term tamoxifen therapy on Ki-67 labelling index in women with primary breast cancer.. International Journal of Oncology, 16, 25-55. https://doi.org/10.3892/ijo.16.1.25
MLA
Dardes, R., Horiguchi, J., Jordan, V."A pilot study of the effects of short-term tamoxifen therapy on Ki-67 labelling index in women with primary breast cancer.". International Journal of Oncology 16.1 (2000): 25-55.
Chicago
Dardes, R., Horiguchi, J., Jordan, V."A pilot study of the effects of short-term tamoxifen therapy on Ki-67 labelling index in women with primary breast cancer.". International Journal of Oncology 16, no. 1 (2000): 25-55. https://doi.org/10.3892/ijo.16.1.25