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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Jan 2000 Volume 16 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Jan 2000 Volume 16 Issue 1

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Article

A pilot study of the effects of short-term tamoxifen therapy on Ki-67 labelling index in women with primary breast cancer.

  • Authors:
    • R D Dardes
    • J Horiguchi
    • V C Jordan

  • View Affiliations / Copyright

    Affiliations: Department of Gynecology, Federal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.
  • Pages: 25-55
    |
    Published online on: January 1, 2000
       https://doi.org/10.3892/ijo.16.1.25
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Abstract

In this study we demonstrate the change in estrogen receptor (ER) level and cell proliferation in human breast cancer after a short-term tamoxifen therapy. Ten pre- and post-treatment breast tumor samples were examined immunohistochemically using ER and Ki-67 antibodies. Before tamoxifen treatment, six (60%) of ten patients were positive for ER. Tamoxifen increased the ER level in one patient and decreased the level in 4 patients. There was no significant change in ER level by tamoxifen therapy. On the other hand, Ki-67 labelling index (LI) significantly decreased after tamoxifen treatment. When Ki-67 LI was analyzed according to ER level, there was no difference between pre- and post-tamoxifen treatment in ER-negative patients, however, a significant decrease of Ki-67 LI by tamoxifen treatment was seen in ER-positive patients. Patients who showed down-regulation of ER expression tended to show a decrease of Ki-67 LI after tamoxifen therapy. In conclusion, short-term tamoxifen therapy decreased the proliferation of breast cancer, in ER-positive breast tumor samples.

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Copy and paste a formatted citation
Spandidos Publications style
Dardes R, Horiguchi J and Jordan V: A pilot study of the effects of short-term tamoxifen therapy on Ki-67 labelling index in women with primary breast cancer.. Int J Oncol 16: 25-55, 2000.
APA
Dardes, R., Horiguchi, J., & Jordan, V. (2000). A pilot study of the effects of short-term tamoxifen therapy on Ki-67 labelling index in women with primary breast cancer.. International Journal of Oncology, 16, 25-55. https://doi.org/10.3892/ijo.16.1.25
MLA
Dardes, R., Horiguchi, J., Jordan, V."A pilot study of the effects of short-term tamoxifen therapy on Ki-67 labelling index in women with primary breast cancer.". International Journal of Oncology 16.1 (2000): 25-55.
Chicago
Dardes, R., Horiguchi, J., Jordan, V."A pilot study of the effects of short-term tamoxifen therapy on Ki-67 labelling index in women with primary breast cancer.". International Journal of Oncology 16, no. 1 (2000): 25-55. https://doi.org/10.3892/ijo.16.1.25
Copy and paste a formatted citation
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Spandidos Publications style
Dardes R, Horiguchi J and Jordan V: A pilot study of the effects of short-term tamoxifen therapy on Ki-67 labelling index in women with primary breast cancer.. Int J Oncol 16: 25-55, 2000.
APA
Dardes, R., Horiguchi, J., & Jordan, V. (2000). A pilot study of the effects of short-term tamoxifen therapy on Ki-67 labelling index in women with primary breast cancer.. International Journal of Oncology, 16, 25-55. https://doi.org/10.3892/ijo.16.1.25
MLA
Dardes, R., Horiguchi, J., Jordan, V."A pilot study of the effects of short-term tamoxifen therapy on Ki-67 labelling index in women with primary breast cancer.". International Journal of Oncology 16.1 (2000): 25-55.
Chicago
Dardes, R., Horiguchi, J., Jordan, V."A pilot study of the effects of short-term tamoxifen therapy on Ki-67 labelling index in women with primary breast cancer.". International Journal of Oncology 16, no. 1 (2000): 25-55. https://doi.org/10.3892/ijo.16.1.25
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