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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May 2000 Volume 16 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2000 Volume 16 Issue 5

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Article

Tyrosine phosphorylation of an erbB-2 related p90 protein induced by estrogen in human breast epithelial cells.

  • Authors:
    • B Wang
    • F R Miller
  • View Affiliations / Copyright

    Affiliations: Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, USA.
  • Pages: 1035-1077
    |
    Published online on: May 1, 2000
       https://doi.org/10.3892/ijo.16.5.1035
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Abstract

Estrogen induced erbB-2 tyrosine kinase activity in human breast epithelial cells irrespective of estrogen receptor expression. MCF10A is an immortal normal human breast epithelial cell line which does not express estrogen receptor. After treatment of MCF10A cells with estradiol-17beta (E2), a phosphorylated 90 kDa protein which co-immunoprecipitates with p185erbB-2 is detected. The response is transient, detected after 1-5 min exposure to E2, and dose dependent, occurring at 10-10 M E2. A similar response was observed for MCF10A cells transfected with an estrogen receptor, estrogen receptor expressing MCF-7 cells, and estrogen receptor-negative MDA-MB-435 cells but at 10-11 M E2. Overexpression of c-erbB-2 in MCF10A cells prolonged the phosphorylated p90 response to E2.

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Copy and paste a formatted citation
Spandidos Publications style
Wang B and Miller F: Tyrosine phosphorylation of an erbB-2 related p90 protein induced by estrogen in human breast epithelial cells.. Int J Oncol 16: 1035-1077, 2000.
APA
Wang, B., & Miller, F. (2000). Tyrosine phosphorylation of an erbB-2 related p90 protein induced by estrogen in human breast epithelial cells.. International Journal of Oncology, 16, 1035-1077. https://doi.org/10.3892/ijo.16.5.1035
MLA
Wang, B., Miller, F."Tyrosine phosphorylation of an erbB-2 related p90 protein induced by estrogen in human breast epithelial cells.". International Journal of Oncology 16.5 (2000): 1035-1077.
Chicago
Wang, B., Miller, F."Tyrosine phosphorylation of an erbB-2 related p90 protein induced by estrogen in human breast epithelial cells.". International Journal of Oncology 16, no. 5 (2000): 1035-1077. https://doi.org/10.3892/ijo.16.5.1035
Copy and paste a formatted citation
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Spandidos Publications style
Wang B and Miller F: Tyrosine phosphorylation of an erbB-2 related p90 protein induced by estrogen in human breast epithelial cells.. Int J Oncol 16: 1035-1077, 2000.
APA
Wang, B., & Miller, F. (2000). Tyrosine phosphorylation of an erbB-2 related p90 protein induced by estrogen in human breast epithelial cells.. International Journal of Oncology, 16, 1035-1077. https://doi.org/10.3892/ijo.16.5.1035
MLA
Wang, B., Miller, F."Tyrosine phosphorylation of an erbB-2 related p90 protein induced by estrogen in human breast epithelial cells.". International Journal of Oncology 16.5 (2000): 1035-1077.
Chicago
Wang, B., Miller, F."Tyrosine phosphorylation of an erbB-2 related p90 protein induced by estrogen in human breast epithelial cells.". International Journal of Oncology 16, no. 5 (2000): 1035-1077. https://doi.org/10.3892/ijo.16.5.1035
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