Fas and Fas ligand interactions in malignant disease.

  • Authors:
    • L Owen-Schaub
    • H Chan
    • J C Cusack
    • J Roth
    • L L Hill
  • View Affiliations

  • Published online on: July 1, 2000     https://doi.org/10.3892/ijo.17.1.5
  • Pages: 5-17
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Abstract

Apoptosis has been implicated in tumor development and progression. Fas (CD95) and Fas ligand (FasL) are an interacting receptor ligand pair that elicits apoptosis in many cell types. Although originally described as proteins regulating peripheral immune tolerance, accumulating evidence suggests that Fas/FasL may play an important role in carcinogenesis, tumor outgrowth, and metastasis. This review summarizes our current knowledge about the regulation of Fas and FasL expression, Fas signaling, soluble Fas production, the role(s) of Fas and FasL in hematopoietic and non-hematopoietic tumorigenesis and progression, and the potential application of Fas-induced apoptosis in cancer therapy.

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Journal Cover

Jul 2000
Volume 17 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Owen-Schaub L, Chan H, Cusack J, Roth J and Hill L: Fas and Fas ligand interactions in malignant disease.. Int J Oncol 17: 5-17, 2000
APA
Owen-Schaub, L., Chan, H., Cusack, J., Roth, J., & Hill, L. (2000). Fas and Fas ligand interactions in malignant disease.. International Journal of Oncology, 17, 5-17. https://doi.org/10.3892/ijo.17.1.5
MLA
Owen-Schaub, L., Chan, H., Cusack, J., Roth, J., Hill, L."Fas and Fas ligand interactions in malignant disease.". International Journal of Oncology 17.1 (2000): 5-17.
Chicago
Owen-Schaub, L., Chan, H., Cusack, J., Roth, J., Hill, L."Fas and Fas ligand interactions in malignant disease.". International Journal of Oncology 17, no. 1 (2000): 5-17. https://doi.org/10.3892/ijo.17.1.5