Stabilization of disease as an indicator of clinical benefit associated with chemotherapy in non-small cell lung cancer patients.

  • Authors:
    • A Cesano
    • S R Lane
    • G A Ross
    • S Z Fields
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  • Published online on: September 1, 2000     https://doi.org/10.3892/ijo.17.3.587
  • Pages: 587-677
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Abstract

In Phase II oncology studies, response rate has traditionally been used to assess activity. However stabilization of disease (SD) may also provide patient benefit. To assess the value of SD (stabilization of measurable disease for at least 8 weeks) as a predictor of survival following chemotherapy in patients with non-small cell lung cancer (NSCLC), we have analyzed data from 198 NSCLC patients receiving topotecan i.v. or orally as first-line therapy either as single agent or in combination. Proportional hazards (Cox) regression models showed that responders [complete response (CR) + partial response (PR), 1.5% and 11.6% respectively] had an estimated risk of death that was 9.8% (95% CI: 4.2% to 22.7%) of that for progressive disease (PD) (60.1% of the patient population). Similarly, patients with SD (26.8% of the patient population) showed a potential benefit with a risk of death that was 27.7% of the one of patients with PD (95% CI: 17.8% to 43.1%). In conclusion SD may be a useful indicator of patient benefit from chemotherapy for NSCLC.

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Sep 2000
Volume 17 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Cesano A, Lane S, Ross G and Fields S: Stabilization of disease as an indicator of clinical benefit associated with chemotherapy in non-small cell lung cancer patients.. Int J Oncol 17: 587-677, 2000.
APA
Cesano, A., Lane, S., Ross, G., & Fields, S. (2000). Stabilization of disease as an indicator of clinical benefit associated with chemotherapy in non-small cell lung cancer patients.. International Journal of Oncology, 17, 587-677. https://doi.org/10.3892/ijo.17.3.587
MLA
Cesano, A., Lane, S., Ross, G., Fields, S."Stabilization of disease as an indicator of clinical benefit associated with chemotherapy in non-small cell lung cancer patients.". International Journal of Oncology 17.3 (2000): 587-677.
Chicago
Cesano, A., Lane, S., Ross, G., Fields, S."Stabilization of disease as an indicator of clinical benefit associated with chemotherapy in non-small cell lung cancer patients.". International Journal of Oncology 17, no. 3 (2000): 587-677. https://doi.org/10.3892/ijo.17.3.587