The Rb family of cell cycle regulatory factors: clinical implications.

  • Authors:
    • V Masciullo
    • K Khalili
    • A Giordano
  • View Affiliations

  • Published online on: November 1, 2000     https://doi.org/10.3892/ijo.17.5.897
  • Pages: 897-1799
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Abstract

The retinoblastoma gene family is composed of three members: the product of the retinoblastoma gene (pRb), which is one of the most well studied tumor suppressor genes and two related proteins, pRb2/p130 and p107, which have been shown to be structurally and functionally similar to pRb. The three retinoblastoma family members show growth suppressive properties, although the growth arrest mediated by each of the three pocket regions of the proteins is not identical. This supports the idea that although the three members may complement each other, they are not fully functional or redundant. Among the three family members, the retinoblastoma-related gene product pRb2/p130 is a tumor suppressor gene and an effective candidate target for gene therapy approach. The aim of this review is to examine the role of the Rb family members in growth regulation discussing their putative prognostic and therapeutical impact in human cancer.

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Nov 2000
Volume 17 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Masciullo V, Khalili K and Giordano A: The Rb family of cell cycle regulatory factors: clinical implications.. Int J Oncol 17: 897-1799, 2000
APA
Masciullo, V., Khalili, K., & Giordano, A. (2000). The Rb family of cell cycle regulatory factors: clinical implications.. International Journal of Oncology, 17, 897-1799. https://doi.org/10.3892/ijo.17.5.897
MLA
Masciullo, V., Khalili, K., Giordano, A."The Rb family of cell cycle regulatory factors: clinical implications.". International Journal of Oncology 17.5 (2000): 897-1799.
Chicago
Masciullo, V., Khalili, K., Giordano, A."The Rb family of cell cycle regulatory factors: clinical implications.". International Journal of Oncology 17, no. 5 (2000): 897-1799. https://doi.org/10.3892/ijo.17.5.897