p53 accumulation confers prognostic information in resectable adenocarcinomas with ductal but not with intestinal differentiation in the pancreatic head.

  • Authors:
    • A Bergan
    • I P Gladhaug
    • A Schjolberg
    • A B Bergan
    • O P Clausen
  • View Affiliations

  • Published online on: November 1, 2000     https://doi.org/10.3892/ijo.17.5.921
  • Pages: 921-927
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Abstract

The aim of the study was to examine the relation between p53 protein accumulation, clinicopathological variables and prognosis in resectable adenocarcinomas of the pancreatic head. The clinical records and tissue specimens of 82 consecutive patients resected for adenocarcinomas located in the head of the pancreas were reviewed retrospectively. Formalin-fixed and paraffin-embedded specimens from each tumour were stained with the monoclonal antibody DO7, and the nuclear p53 positivity within each tumour was assessed. Histopathological reclassification showed that 60 tumours exhibited ductal differentiation and 22 tumours intestinal differentiation. Twenty-five percent (15/60) of the ductal tumours and 50% (11/22) of the intestinal tumours were positive for p53 accumulation. p53 immunoreactivity was significantly correlated to a worse prognosis in the tumours of ductal differentiation, with median survival 0.76 years for p53 positive and 1.44 years for p53 negative patients. The p53 positivity of tumours with intestinal differentiation showed no such correlation. No correlation was found between p53 accumulation and other known prognostic factors in either the ductal or the intestinal type of tumours. Our results indicate that the tumour biology of ductal adenocarcinomas differs significantly from that of adenocarcinomas of the intestinal type located in the pancreatic head, and that p53 accumulation confers a worse prognosis only of ductal tumours. Subclassification of these tumours based on type of differentiation is therefore suggested since periampullary tumours include ductally as well as intestinally differentiated adenocarcinomas.

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Nov 2000
Volume 17 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Bergan A, Gladhaug I, Schjolberg A, Bergan A and Clausen O: p53 accumulation confers prognostic information in resectable adenocarcinomas with ductal but not with intestinal differentiation in the pancreatic head.. Int J Oncol 17: 921-927, 2000
APA
Bergan, A., Gladhaug, I., Schjolberg, A., Bergan, A., & Clausen, O. (2000). p53 accumulation confers prognostic information in resectable adenocarcinomas with ductal but not with intestinal differentiation in the pancreatic head.. International Journal of Oncology, 17, 921-927. https://doi.org/10.3892/ijo.17.5.921
MLA
Bergan, A., Gladhaug, I., Schjolberg, A., Bergan, A., Clausen, O."p53 accumulation confers prognostic information in resectable adenocarcinomas with ductal but not with intestinal differentiation in the pancreatic head.". International Journal of Oncology 17.5 (2000): 921-927.
Chicago
Bergan, A., Gladhaug, I., Schjolberg, A., Bergan, A., Clausen, O."p53 accumulation confers prognostic information in resectable adenocarcinomas with ductal but not with intestinal differentiation in the pancreatic head.". International Journal of Oncology 17, no. 5 (2000): 921-927. https://doi.org/10.3892/ijo.17.5.921