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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Nov 2000 Volume 17 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Nov 2000 Volume 17 Issue 5

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Article

Inhibition of cell growth and telomerase activity of breast cancer cells in vitro by retinoic acids.

  • Authors:
    • S H Choi
    • H K Kang
    • E O Im
    • Y J Kim
    • Y T Bae
    • Y H Choi
    • K H Lee
    • H Y Chung
    • H K Chang
    • N D Kim

  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, Pusan National University, Pusan 609-735, Korea.
  • Pages: 971-977
    |
    Published online on: November 1, 2000
       https://doi.org/10.3892/ijo.17.5.971
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Abstract

The effects of retinoic acid (RA) and its analogs, all-trans RA, 9-cis RA and 13-cis RA, were investigated in human breast cancer MCF-7 cells and immortalized breast epithelial cell line MCF-10A. RA inhibited the telomerase activity of MCF-7 cells in a wide range of concentrations. RA at 10 microM also inhibited the growth of MCF-7 cells in a time-dependent manner. However, no significant growth inhibition was found between untreated control and RA-treated MCF-10A cells. Moreover, a marked inhibition of telomerase activity by RA was detected early in MCF-7 cells (after 24 h of RA treatment), which was preceded by a reduction of hTERT mRNA expression (after 12 h of RA treatment). However, MCF-10A cells showed a reduction of telomerase activity and down-regulation of hTERT after 4 days of RA treatment. Simultaneous changes in hTERT mRNA expression and telomerase activity were found for MCF-10A cells. The expressions of hTR and hTEP1 telomerase component genes were not changed after RA treatment. These results indicate that the anti-breast cancer activity of RA could be mediated by its ability to down-regulate the expression of hTERT telomerase gene.

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Copy and paste a formatted citation
Spandidos Publications style
Choi S, Kang H, Im E, Kim Y, Bae Y, Choi Y, Lee K, Chung H, Chang H, Kim N, Kim N, et al: Inhibition of cell growth and telomerase activity of breast cancer cells in vitro by retinoic acids.. Int J Oncol 17: 971-977, 2000.
APA
Choi, S., Kang, H., Im, E., Kim, Y., Bae, Y., Choi, Y. ... Kim, N. (2000). Inhibition of cell growth and telomerase activity of breast cancer cells in vitro by retinoic acids.. International Journal of Oncology, 17, 971-977. https://doi.org/10.3892/ijo.17.5.971
MLA
Choi, S., Kang, H., Im, E., Kim, Y., Bae, Y., Choi, Y., Lee, K., Chung, H., Chang, H., Kim, N."Inhibition of cell growth and telomerase activity of breast cancer cells in vitro by retinoic acids.". International Journal of Oncology 17.5 (2000): 971-977.
Chicago
Choi, S., Kang, H., Im, E., Kim, Y., Bae, Y., Choi, Y., Lee, K., Chung, H., Chang, H., Kim, N."Inhibition of cell growth and telomerase activity of breast cancer cells in vitro by retinoic acids.". International Journal of Oncology 17, no. 5 (2000): 971-977. https://doi.org/10.3892/ijo.17.5.971
Copy and paste a formatted citation
x
Spandidos Publications style
Choi S, Kang H, Im E, Kim Y, Bae Y, Choi Y, Lee K, Chung H, Chang H, Kim N, Kim N, et al: Inhibition of cell growth and telomerase activity of breast cancer cells in vitro by retinoic acids.. Int J Oncol 17: 971-977, 2000.
APA
Choi, S., Kang, H., Im, E., Kim, Y., Bae, Y., Choi, Y. ... Kim, N. (2000). Inhibition of cell growth and telomerase activity of breast cancer cells in vitro by retinoic acids.. International Journal of Oncology, 17, 971-977. https://doi.org/10.3892/ijo.17.5.971
MLA
Choi, S., Kang, H., Im, E., Kim, Y., Bae, Y., Choi, Y., Lee, K., Chung, H., Chang, H., Kim, N."Inhibition of cell growth and telomerase activity of breast cancer cells in vitro by retinoic acids.". International Journal of Oncology 17.5 (2000): 971-977.
Chicago
Choi, S., Kang, H., Im, E., Kim, Y., Bae, Y., Choi, Y., Lee, K., Chung, H., Chang, H., Kim, N."Inhibition of cell growth and telomerase activity of breast cancer cells in vitro by retinoic acids.". International Journal of Oncology 17, no. 5 (2000): 971-977. https://doi.org/10.3892/ijo.17.5.971
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