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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 2001 Volume 18 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2001 Volume 18 Issue 2

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Article

Enhanced TRAIL sensitivity by p53 overexpression in human cancer but not normal cell lines

  • Authors:
    • Kunhong Kim
    • Rishu Takimoto
    • David T. Dicker
    • Youhai Chen
    • Yair Gazitt
    • Wafik S. El-Deiry

  • View Affiliations / Copyright

    Affiliations: Laboratory of Molecular Oncology and Cell Cycle Regulation, Howard Hughes Medical Institute, Departments of Medicine, Genetics, and Pharmacology, and the Institute for Human Gene Therapy, Philadelphia, PA 19104, USA
  • Pages: 241-247
    |
    Published online on: February 1, 2001
       https://doi.org/10.3892/ijo.18.2.241
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Abstract

The cytotoxic ligand TRAIL is a promising anti-cancer agent that is entering into clinical trials. We previously identified a major subgroup of TRAIL resistant cancer cell lines with absent, or reduced DR4 expression containing a K441R polymorphism or harboring elevated levels of the caspase activation inhibitor FLIP. In the present study, we explored the use of a gene therapeutic approach utilizing p53, delivered by an adenovirus-p53 (Ad-p53) vector, which directly controls expression of the TRAIL receptor KILLER/DR5 in a panel of 8 cell lines including normal and TRAIL sensitive or resistant cancers. The functional status of the delivered p53 was monitored by detection of induced p21WAF1 expression by immunocytochemistry. In normal cells, which are TRAIL resistant, TRAIL did not reduce cell viability over and above the effect of Ad-p53 alone. All cancer cell lines were sensitive to Ad-p53 and up-regulated expression of the TRAIL receptor KILLER/DR5. TRAIL-resistant cancer cells became more sensitive to TRAIL at low Ad-p53 multiplicities of infection but TRAIL resistance was not completely overcome in one TRAIL-resistant cell line probably because of a high level of expression of FLIP. The results reveal that Ad-p53 induces the TRAIL receptor KILLER/DR5 and, like radiation or chemotherapy may effectively reverse TRAIL resistance.

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Copy and paste a formatted citation
Spandidos Publications style
Kim K, Takimoto R, Dicker DT, Chen Y, Gazitt Y and El-Deiry WS: Enhanced TRAIL sensitivity by p53 overexpression in human cancer but not normal cell lines. Int J Oncol 18: 241-247, 2001.
APA
Kim, K., Takimoto, R., Dicker, D.T., Chen, Y., Gazitt, Y., & El-Deiry, W.S. (2001). Enhanced TRAIL sensitivity by p53 overexpression in human cancer but not normal cell lines. International Journal of Oncology, 18, 241-247. https://doi.org/10.3892/ijo.18.2.241
MLA
Kim, K., Takimoto, R., Dicker, D. T., Chen, Y., Gazitt, Y., El-Deiry, W. S."Enhanced TRAIL sensitivity by p53 overexpression in human cancer but not normal cell lines". International Journal of Oncology 18.2 (2001): 241-247.
Chicago
Kim, K., Takimoto, R., Dicker, D. T., Chen, Y., Gazitt, Y., El-Deiry, W. S."Enhanced TRAIL sensitivity by p53 overexpression in human cancer but not normal cell lines". International Journal of Oncology 18, no. 2 (2001): 241-247. https://doi.org/10.3892/ijo.18.2.241
Copy and paste a formatted citation
x
Spandidos Publications style
Kim K, Takimoto R, Dicker DT, Chen Y, Gazitt Y and El-Deiry WS: Enhanced TRAIL sensitivity by p53 overexpression in human cancer but not normal cell lines. Int J Oncol 18: 241-247, 2001.
APA
Kim, K., Takimoto, R., Dicker, D.T., Chen, Y., Gazitt, Y., & El-Deiry, W.S. (2001). Enhanced TRAIL sensitivity by p53 overexpression in human cancer but not normal cell lines. International Journal of Oncology, 18, 241-247. https://doi.org/10.3892/ijo.18.2.241
MLA
Kim, K., Takimoto, R., Dicker, D. T., Chen, Y., Gazitt, Y., El-Deiry, W. S."Enhanced TRAIL sensitivity by p53 overexpression in human cancer but not normal cell lines". International Journal of Oncology 18.2 (2001): 241-247.
Chicago
Kim, K., Takimoto, R., Dicker, D. T., Chen, Y., Gazitt, Y., El-Deiry, W. S."Enhanced TRAIL sensitivity by p53 overexpression in human cancer but not normal cell lines". International Journal of Oncology 18, no. 2 (2001): 241-247. https://doi.org/10.3892/ijo.18.2.241
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