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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 2001 Volume 18 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2001 Volume 18 Issue 2

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Article

Differential sensitization by orobol in proliferating and quiescent human ovarian carcinoma cells

  • Authors:
    • S. Shiotsuka
    • S. Isonishi

  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics/Gynecology, Jikei University School of Medicine, Minato-ku, Tokyo 105, Japan
  • Pages: 337-342
    |
    Published online on: February 1, 2001
       https://doi.org/10.3892/ijo.18.2.337
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Abstract

The object of this study was to determine how phosphatidylinositol (PI) signaling pathway is involved in the regulation of cisplatin (DDP) sensitivity. Clonogenic survival assay was used to determine the effect of orobol, a potent PI4-kinase inhibitor, on DDP sensitivity in human ovarian carcinoma 2008 cells. Orobol enhanced sensitivity to DDP in 2008 cells by a factor of 2.1±0.4 (SD)-fold (N=3; P<0.01). Sensitization was specific for proliferating cells. Orobol did not alter DDP sensitivity in quiescent cells. Orobol also produced a 2-fold increase in sensitivity to DDP in proliferating 2008/C13*5.25 DDP-resistant variants. Our studies indicated that orobol-induced sensitization depended on the presence of proliferating cells in G2+M phase of the cell cycle. Orobol did not modulate the cellular accumulation of DDP nor did it alter the CdCl2 sensitivity, suggesting that the amount of platinated-DNA was not changed by orobol treatment. However, orobol rendered 2008 cells resistant to rhodamin 123 by 5.7±1.7 (SD)-fold (N=3, P<0.01). Since sensitivity to rhodamin 123 is indicative of mitochondrial membrane potential, these results imply that mitochondrial alterations may be an important component of the orobol sensitization effect in these cells.

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Copy and paste a formatted citation
Spandidos Publications style
Shiotsuka S and Isonishi S: Differential sensitization by orobol in proliferating and quiescent human ovarian carcinoma cells. Int J Oncol 18: 337-342, 2001.
APA
Shiotsuka, S., & Isonishi, S. (2001). Differential sensitization by orobol in proliferating and quiescent human ovarian carcinoma cells. International Journal of Oncology, 18, 337-342. https://doi.org/10.3892/ijo.18.2.337
MLA
Shiotsuka, S., Isonishi, S."Differential sensitization by orobol in proliferating and quiescent human ovarian carcinoma cells". International Journal of Oncology 18.2 (2001): 337-342.
Chicago
Shiotsuka, S., Isonishi, S."Differential sensitization by orobol in proliferating and quiescent human ovarian carcinoma cells". International Journal of Oncology 18, no. 2 (2001): 337-342. https://doi.org/10.3892/ijo.18.2.337
Copy and paste a formatted citation
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Spandidos Publications style
Shiotsuka S and Isonishi S: Differential sensitization by orobol in proliferating and quiescent human ovarian carcinoma cells. Int J Oncol 18: 337-342, 2001.
APA
Shiotsuka, S., & Isonishi, S. (2001). Differential sensitization by orobol in proliferating and quiescent human ovarian carcinoma cells. International Journal of Oncology, 18, 337-342. https://doi.org/10.3892/ijo.18.2.337
MLA
Shiotsuka, S., Isonishi, S."Differential sensitization by orobol in proliferating and quiescent human ovarian carcinoma cells". International Journal of Oncology 18.2 (2001): 337-342.
Chicago
Shiotsuka, S., Isonishi, S."Differential sensitization by orobol in proliferating and quiescent human ovarian carcinoma cells". International Journal of Oncology 18, no. 2 (2001): 337-342. https://doi.org/10.3892/ijo.18.2.337
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