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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 2001 Volume 18 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2001 Volume 18 Issue 2

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Article

Co-expression of E2F-2 enhances the p53 anti-cancer effect in human glioma cells

  • Authors:
    • P. G. Mitlianga
    • A. P. Kyritsis
    • C. Gomez-Manzano
    • M. G. Lemoine
    • M. Hu
    • T.-J. Liu
    • W. K.A. Yung
    • J. Fueyo

  • View Affiliations / Copyright

    Affiliations: Department of Neuro-Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
  • Pages: 343-347
    |
    Published online on: February 1, 2001
       https://doi.org/10.3892/ijo.18.2.343
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Abstract

Gliomas are highly resistant to conventional treatment. Improved knowledge of the molecular defects of glioma cells offers new avenues for the development of gene therapy strategies. Transfer of the p53 gene has proven effective in suppressing proliferation in human glioma cell lines. However, several human glioma cell lines are resistant to p53-induced cell death. The E2F family of transcription factors are pivotal for the regulation of cell-cycle and cell-death related genes in gliomas. In the present study, we sought a more effective strategy for glioma treatment by examining the therapeutic potential of the simultaneous transfer of p53 and E2F-2 to gliomas. Trypan blue cell viability assays and flow cytometric cell-cycle analysis demonstrated that the transfer of both p53 and E2F-2 induced cell death in D-54 MG, a p53-resistant glioma cell line. In addition, transfer of E2F-2 did not interfere with the apoptotic properties of exogenous wild-type p53 in U-251 MG cells. Finally, the expression of E2F-2 in D-54 MG cells suppressed the expression of the apoptotic molecule mdm-2 induced by exogenous p53 in these cells. These results show that co-expression of E2F-2 and p53 enhances the anti-cancer effect of p53 in gliomas.

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Copy and paste a formatted citation
Spandidos Publications style
Mitlianga PG, Kyritsis AP, Gomez-Manzano C, Lemoine MG, Hu M, Liu T, Yung WK and Fueyo J: Co-expression of E2F-2 enhances the p53 anti-cancer effect in human glioma cells. Int J Oncol 18: 343-347, 2001.
APA
Mitlianga, P.G., Kyritsis, A.P., Gomez-Manzano, C., Lemoine, M.G., Hu, M., Liu, T. ... Fueyo, J. (2001). Co-expression of E2F-2 enhances the p53 anti-cancer effect in human glioma cells. International Journal of Oncology, 18, 343-347. https://doi.org/10.3892/ijo.18.2.343
MLA
Mitlianga, P. G., Kyritsis, A. P., Gomez-Manzano, C., Lemoine, M. G., Hu, M., Liu, T., Yung, W. K., Fueyo, J."Co-expression of E2F-2 enhances the p53 anti-cancer effect in human glioma cells". International Journal of Oncology 18.2 (2001): 343-347.
Chicago
Mitlianga, P. G., Kyritsis, A. P., Gomez-Manzano, C., Lemoine, M. G., Hu, M., Liu, T., Yung, W. K., Fueyo, J."Co-expression of E2F-2 enhances the p53 anti-cancer effect in human glioma cells". International Journal of Oncology 18, no. 2 (2001): 343-347. https://doi.org/10.3892/ijo.18.2.343
Copy and paste a formatted citation
x
Spandidos Publications style
Mitlianga PG, Kyritsis AP, Gomez-Manzano C, Lemoine MG, Hu M, Liu T, Yung WK and Fueyo J: Co-expression of E2F-2 enhances the p53 anti-cancer effect in human glioma cells. Int J Oncol 18: 343-347, 2001.
APA
Mitlianga, P.G., Kyritsis, A.P., Gomez-Manzano, C., Lemoine, M.G., Hu, M., Liu, T. ... Fueyo, J. (2001). Co-expression of E2F-2 enhances the p53 anti-cancer effect in human glioma cells. International Journal of Oncology, 18, 343-347. https://doi.org/10.3892/ijo.18.2.343
MLA
Mitlianga, P. G., Kyritsis, A. P., Gomez-Manzano, C., Lemoine, M. G., Hu, M., Liu, T., Yung, W. K., Fueyo, J."Co-expression of E2F-2 enhances the p53 anti-cancer effect in human glioma cells". International Journal of Oncology 18.2 (2001): 343-347.
Chicago
Mitlianga, P. G., Kyritsis, A. P., Gomez-Manzano, C., Lemoine, M. G., Hu, M., Liu, T., Yung, W. K., Fueyo, J."Co-expression of E2F-2 enhances the p53 anti-cancer effect in human glioma cells". International Journal of Oncology 18, no. 2 (2001): 343-347. https://doi.org/10.3892/ijo.18.2.343
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