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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 2001 Volume 18 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2001 Volume 18 Issue 2

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Article

Wild-type p53 marginally induces endogenous MDR-1 mRNA without causing a measurable drug resistance in human cancer cells

  • Authors:
    • Maria Ines Nicoletti
    • Timothy G. Myers
    • Tito Fojo
    • Mikhail V. Blagosklonny

  • View Affiliations / Copyright

    Affiliations: Medicine Branch and Developmental Therapeutics Program, National Cancer Institute, NIH, Bethesda, MD 20892, USA
  • Pages: 375-381
    |
    Published online on: February 1, 2001
       https://doi.org/10.3892/ijo.18.2.375
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Abstract

The notion that wt p53 downregulates MDR-1 links p53 mutations to multidrug resistant phenotype. Alternatively, it has been envisioned that wt p53 protects cells against DNA damaging drugs by inducing MDR-1. Opposing conclusions on the relationship between MDR-1 and p53 have been predominantly based on the effects of p53 on MDR-1 promoter-constructs. We found that introduction of wt p53 slightly induced MDR-1 mRNA in three cell lines having endogenous mt p53. Wt p53-mediated induction of endogenous MDR-1 may represent a rudiment of cellular protection against toxic compounds earlier in evolution. Marked induction of p21WAF1/CIP1 (p21) mRNA was observed in all cell lines; and lower levels of wt p53 were required to induce p21 than MDR-1. Pgp was undetectable and wt p53 did not increase resistance to an MDR-1 substrate, suggesting the changes in MDR-1 mRNA may be functionally insignificant. Unlike endogenous MDR-1, the expression of an MDR-1 promoter (-434/+147 fragment) - luciferase construct was unchanged or even inhibited by wt p53 that may be secondary to wt p53-mediated cytotoxicity. Thus, partial promoter constructs may not accurately represent endogenous MDR-1.

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Copy and paste a formatted citation
Spandidos Publications style
Nicoletti MI, Myers TG, Fojo T and Blagosklonny MV: Wild-type p53 marginally induces endogenous MDR-1 mRNA without causing a measurable drug resistance in human cancer cells. Int J Oncol 18: 375-381, 2001.
APA
Nicoletti, M.I., Myers, T.G., Fojo, T., & Blagosklonny, M.V. (2001). Wild-type p53 marginally induces endogenous MDR-1 mRNA without causing a measurable drug resistance in human cancer cells. International Journal of Oncology, 18, 375-381. https://doi.org/10.3892/ijo.18.2.375
MLA
Nicoletti, M. I., Myers, T. G., Fojo, T., Blagosklonny, M. V."Wild-type p53 marginally induces endogenous MDR-1 mRNA without causing a measurable drug resistance in human cancer cells". International Journal of Oncology 18.2 (2001): 375-381.
Chicago
Nicoletti, M. I., Myers, T. G., Fojo, T., Blagosklonny, M. V."Wild-type p53 marginally induces endogenous MDR-1 mRNA without causing a measurable drug resistance in human cancer cells". International Journal of Oncology 18, no. 2 (2001): 375-381. https://doi.org/10.3892/ijo.18.2.375
Copy and paste a formatted citation
x
Spandidos Publications style
Nicoletti MI, Myers TG, Fojo T and Blagosklonny MV: Wild-type p53 marginally induces endogenous MDR-1 mRNA without causing a measurable drug resistance in human cancer cells. Int J Oncol 18: 375-381, 2001.
APA
Nicoletti, M.I., Myers, T.G., Fojo, T., & Blagosklonny, M.V. (2001). Wild-type p53 marginally induces endogenous MDR-1 mRNA without causing a measurable drug resistance in human cancer cells. International Journal of Oncology, 18, 375-381. https://doi.org/10.3892/ijo.18.2.375
MLA
Nicoletti, M. I., Myers, T. G., Fojo, T., Blagosklonny, M. V."Wild-type p53 marginally induces endogenous MDR-1 mRNA without causing a measurable drug resistance in human cancer cells". International Journal of Oncology 18.2 (2001): 375-381.
Chicago
Nicoletti, M. I., Myers, T. G., Fojo, T., Blagosklonny, M. V."Wild-type p53 marginally induces endogenous MDR-1 mRNA without causing a measurable drug resistance in human cancer cells". International Journal of Oncology 18, no. 2 (2001): 375-381. https://doi.org/10.3892/ijo.18.2.375
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