Endogenous production of IL-8 by human colorectal cancer cells and its regulation by cytokines

  • Authors:
    • S. J. Wigmore
    • J. P. Maingay
    • K. C.H. Fearon
    • J. A. Ross
  • View Affiliations

  • Published online on: March 1, 2001     https://doi.org/10.3892/ijo.18.3.467
  • Pages: 467-473
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

This study investigated the endogenous production of the pro-inflammatory and angiogenic cytokine IL-8 by human colorectal cancer cells. We describe substantial (>0.5 ng/ml) constitutive production of IL-8 by certain human colorectal cancer cell lines without the requirement for exogenous stimulation. Tumour cell-derived IL-8 production was upregulated by the addition of the pro-inflammatory type 1 cytokines TNFα, IL-1β and IFNγ. Addition of the regulatory type 2 cytokines IL-4 and IL-10 produced paradoxical stimulation of IL-8 production in certain cell lines and downregulation of IL-8 production in others. These results suggest that tumour-derived cytokine production may have an important role in patients with colorectal cancer. Furthermore, they demonstrate the complexity of tumour cell cytokine production and highlight the difficulties in developing effective therapeutic biological response strategies.

Related Articles

Journal Cover

March 2001
Volume 18 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Wigmore SJ, Maingay JP, Fearon KC and Ross JA: Endogenous production of IL-8 by human colorectal cancer cells and its regulation by cytokines. Int J Oncol 18: 467-473, 2001
APA
Wigmore, S.J., Maingay, J.P., Fearon, K.C., & Ross, J.A. (2001). Endogenous production of IL-8 by human colorectal cancer cells and its regulation by cytokines. International Journal of Oncology, 18, 467-473. https://doi.org/10.3892/ijo.18.3.467
MLA
Wigmore, S. J., Maingay, J. P., Fearon, K. C., Ross, J. A."Endogenous production of IL-8 by human colorectal cancer cells and its regulation by cytokines". International Journal of Oncology 18.3 (2001): 467-473.
Chicago
Wigmore, S. J., Maingay, J. P., Fearon, K. C., Ross, J. A."Endogenous production of IL-8 by human colorectal cancer cells and its regulation by cytokines". International Journal of Oncology 18, no. 3 (2001): 467-473. https://doi.org/10.3892/ijo.18.3.467