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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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March 2001 Volume 18 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 2001 Volume 18 Issue 3

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Article

Endogenous production of IL-8 by human colorectal cancer cells and its regulation by cytokines

  • Authors:
    • S. J. Wigmore
    • J. P. Maingay
    • K. C.H. Fearon
    • J. A. Ross

  • View Affiliations / Copyright

    Affiliations: University Department of Surgery, Royal Infirmary of Edinburgh, Edinburgh, EH3 9YW, UK
  • Pages: 467-473
    |
    Published online on: March 1, 2001
       https://doi.org/10.3892/ijo.18.3.467
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Abstract

This study investigated the endogenous production of the pro-inflammatory and angiogenic cytokine IL-8 by human colorectal cancer cells. We describe substantial (>0.5 ng/ml) constitutive production of IL-8 by certain human colorectal cancer cell lines without the requirement for exogenous stimulation. Tumour cell-derived IL-8 production was upregulated by the addition of the pro-inflammatory type 1 cytokines TNFα, IL-1β and IFNγ. Addition of the regulatory type 2 cytokines IL-4 and IL-10 produced paradoxical stimulation of IL-8 production in certain cell lines and downregulation of IL-8 production in others. These results suggest that tumour-derived cytokine production may have an important role in patients with colorectal cancer. Furthermore, they demonstrate the complexity of tumour cell cytokine production and highlight the difficulties in developing effective therapeutic biological response strategies.

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Copy and paste a formatted citation
Spandidos Publications style
Wigmore SJ, Maingay JP, Fearon KC and Ross JA: Endogenous production of IL-8 by human colorectal cancer cells and its regulation by cytokines. Int J Oncol 18: 467-473, 2001.
APA
Wigmore, S.J., Maingay, J.P., Fearon, K.C., & Ross, J.A. (2001). Endogenous production of IL-8 by human colorectal cancer cells and its regulation by cytokines. International Journal of Oncology, 18, 467-473. https://doi.org/10.3892/ijo.18.3.467
MLA
Wigmore, S. J., Maingay, J. P., Fearon, K. C., Ross, J. A."Endogenous production of IL-8 by human colorectal cancer cells and its regulation by cytokines". International Journal of Oncology 18.3 (2001): 467-473.
Chicago
Wigmore, S. J., Maingay, J. P., Fearon, K. C., Ross, J. A."Endogenous production of IL-8 by human colorectal cancer cells and its regulation by cytokines". International Journal of Oncology 18, no. 3 (2001): 467-473. https://doi.org/10.3892/ijo.18.3.467
Copy and paste a formatted citation
x
Spandidos Publications style
Wigmore SJ, Maingay JP, Fearon KC and Ross JA: Endogenous production of IL-8 by human colorectal cancer cells and its regulation by cytokines. Int J Oncol 18: 467-473, 2001.
APA
Wigmore, S.J., Maingay, J.P., Fearon, K.C., & Ross, J.A. (2001). Endogenous production of IL-8 by human colorectal cancer cells and its regulation by cytokines. International Journal of Oncology, 18, 467-473. https://doi.org/10.3892/ijo.18.3.467
MLA
Wigmore, S. J., Maingay, J. P., Fearon, K. C., Ross, J. A."Endogenous production of IL-8 by human colorectal cancer cells and its regulation by cytokines". International Journal of Oncology 18.3 (2001): 467-473.
Chicago
Wigmore, S. J., Maingay, J. P., Fearon, K. C., Ross, J. A."Endogenous production of IL-8 by human colorectal cancer cells and its regulation by cytokines". International Journal of Oncology 18, no. 3 (2001): 467-473. https://doi.org/10.3892/ijo.18.3.467
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