New murine cell line derived from a spontaneous lung tumor induces paraneoplastic syndromes

  • Authors:
    • A. J. Urtreger
    • M. J. Diament
    • S. M. Ranuncolo
    • M. Del C. Vidal
    • L. I. Puricelli
    • S. M. Klein
    • E. D. Bal de Kier Joffe
  • View Affiliations

  • Published online on: March 1, 2001     https://doi.org/10.3892/ijo.18.3.639
  • Pages: 639-647
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Abstract

LP07 is a new cell line derived from P07 lung tumor, spontaneously arisen in a BALB/c mouse. LP07 is composed of heterogeneous epithelioid polyhedric cells that proliferate at a slow rate, have low plating efficiency and are unable to grow in soft agar. Only some LP07 cells expressed cytokeratins while most of them were positive for vimentin. Ultrastructure studies showed that LP07 cells established rudimentary intercellular unions, formed glandular-like conducts and presented conspicuous secretory granules, suggesting an epithelial-glandular origin, with neuroendocrine components. Upon injection LP07 cells formed poorly differentiated non-invasive adenocarcinomas, and tumor bearing mice developed leukocytosis, hypercalcemia and cachexia. This tumor cell line constitutes a useful tool to study lung tumor biology and paraneoplastic syndromes.

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March 2001
Volume 18 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Urtreger AJ, Diament MJ, Ranuncolo SM, Del C. Vidal M, Puricelli LI, Klein SM and Bal de Kier Joffe ED: New murine cell line derived from a spontaneous lung tumor induces paraneoplastic syndromes. Int J Oncol 18: 639-647, 2001
APA
Urtreger, A.J., Diament, M.J., Ranuncolo, S.M., Del C. Vidal, M., Puricelli, L.I., Klein, S.M., & Bal de Kier Joffe, E.D. (2001). New murine cell line derived from a spontaneous lung tumor induces paraneoplastic syndromes. International Journal of Oncology, 18, 639-647. https://doi.org/10.3892/ijo.18.3.639
MLA
Urtreger, A. J., Diament, M. J., Ranuncolo, S. M., Del C. Vidal, M., Puricelli, L. I., Klein, S. M., Bal de Kier Joffe, E. D."New murine cell line derived from a spontaneous lung tumor induces paraneoplastic syndromes". International Journal of Oncology 18.3 (2001): 639-647.
Chicago
Urtreger, A. J., Diament, M. J., Ranuncolo, S. M., Del C. Vidal, M., Puricelli, L. I., Klein, S. M., Bal de Kier Joffe, E. D."New murine cell line derived from a spontaneous lung tumor induces paraneoplastic syndromes". International Journal of Oncology 18, no. 3 (2001): 639-647. https://doi.org/10.3892/ijo.18.3.639