search button

Analysis of the p53 gene in parotid gland cancers: a relatively high frequency of mutations in low-grade mucoepidermoid carcinomas

  • Authors:
    • Hiroyuki Mutoh
    • Hiroshi Nagata
    • Kazuto Ohno
    • Tsutomu Numata
    • Toshitaka Nagao
    • Koichi Nagao
    • Akiyoshi Konno

  • View Affiliations

  • Published online on: April 1, 2001     https://doi.org/10.3892/ijo.18.4.781
  • Pages: 781-786
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Mutations and overexpression of the p53 gene and protein were analyzed in 40 cases with various types of parotid gland cancers. Mutations were found in 12 cases (30%), and low-grade mucoepidermoid carcinomas (43%) and highly malignant carcinomas including adenocarcinoma, salivary duct carcinoma, and undifferentiated carcinoma (56%) showed a relatively high frequency of mutations. Overexpression of the protein was observed in 11 cases (28%) and 4 of the 11 cases also had p53 mutations. These results suggest that mutations of the p53 gene have significance in certain types of parotid cancers irrespective of the aggressiveness of a tumor type.

Related Articles

Journal Cover

April 2001
Volume 18 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 5.2
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 11.4
  • CiteScore Rank: Q1: #40/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 1.125
  • SCImago Journal Rank (SJR): 1.105
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Mutoh H, Nagata H, Ohno K, Numata T, Nagao T, Nagao K and Konno A: Analysis of the p53 gene in parotid gland cancers: a relatively high frequency of mutations in low-grade mucoepidermoid carcinomas. Int J Oncol 18: 781-786, 2001
APA
Mutoh, H., Nagata, H., Ohno, K., Numata, T., Nagao, T., Nagao, K., & Konno, A. (2001). Analysis of the p53 gene in parotid gland cancers: a relatively high frequency of mutations in low-grade mucoepidermoid carcinomas. International Journal of Oncology, 18, 781-786. https://doi.org/10.3892/ijo.18.4.781
MLA
Mutoh, H., Nagata, H., Ohno, K., Numata, T., Nagao, T., Nagao, K., Konno, A."Analysis of the p53 gene in parotid gland cancers: a relatively high frequency of mutations in low-grade mucoepidermoid carcinomas". International Journal of Oncology 18.4 (2001): 781-786.
Chicago
Mutoh, H., Nagata, H., Ohno, K., Numata, T., Nagao, T., Nagao, K., Konno, A."Analysis of the p53 gene in parotid gland cancers: a relatively high frequency of mutations in low-grade mucoepidermoid carcinomas". International Journal of Oncology 18, no. 4 (2001): 781-786. https://doi.org/10.3892/ijo.18.4.781