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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April 2001 Volume 18 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 2001 Volume 18 Issue 4

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Article

Analysis of the p53 gene in parotid gland cancers: a relatively high frequency of mutations in low-grade mucoepidermoid carcinomas

  • Authors:
    • Hiroyuki Mutoh
    • Hiroshi Nagata
    • Kazuto Ohno
    • Tsutomu Numata
    • Toshitaka Nagao
    • Koichi Nagao
    • Akiyoshi Konno

  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolaryngology, Chiba University, School of Medicine, Chuoh-ku, Chiba 260-8670, Japan
  • Pages: 781-786
    |
    Published online on: April 1, 2001
       https://doi.org/10.3892/ijo.18.4.781
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Abstract

Mutations and overexpression of the p53 gene and protein were analyzed in 40 cases with various types of parotid gland cancers. Mutations were found in 12 cases (30%), and low-grade mucoepidermoid carcinomas (43%) and highly malignant carcinomas including adenocarcinoma, salivary duct carcinoma, and undifferentiated carcinoma (56%) showed a relatively high frequency of mutations. Overexpression of the protein was observed in 11 cases (28%) and 4 of the 11 cases also had p53 mutations. These results suggest that mutations of the p53 gene have significance in certain types of parotid cancers irrespective of the aggressiveness of a tumor type.

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Copy and paste a formatted citation
Spandidos Publications style
Mutoh H, Nagata H, Ohno K, Numata T, Nagao T, Nagao K and Konno A: Analysis of the p53 gene in parotid gland cancers: a relatively high frequency of mutations in low-grade mucoepidermoid carcinomas. Int J Oncol 18: 781-786, 2001.
APA
Mutoh, H., Nagata, H., Ohno, K., Numata, T., Nagao, T., Nagao, K., & Konno, A. (2001). Analysis of the p53 gene in parotid gland cancers: a relatively high frequency of mutations in low-grade mucoepidermoid carcinomas. International Journal of Oncology, 18, 781-786. https://doi.org/10.3892/ijo.18.4.781
MLA
Mutoh, H., Nagata, H., Ohno, K., Numata, T., Nagao, T., Nagao, K., Konno, A."Analysis of the p53 gene in parotid gland cancers: a relatively high frequency of mutations in low-grade mucoepidermoid carcinomas". International Journal of Oncology 18.4 (2001): 781-786.
Chicago
Mutoh, H., Nagata, H., Ohno, K., Numata, T., Nagao, T., Nagao, K., Konno, A."Analysis of the p53 gene in parotid gland cancers: a relatively high frequency of mutations in low-grade mucoepidermoid carcinomas". International Journal of Oncology 18, no. 4 (2001): 781-786. https://doi.org/10.3892/ijo.18.4.781
Copy and paste a formatted citation
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Spandidos Publications style
Mutoh H, Nagata H, Ohno K, Numata T, Nagao T, Nagao K and Konno A: Analysis of the p53 gene in parotid gland cancers: a relatively high frequency of mutations in low-grade mucoepidermoid carcinomas. Int J Oncol 18: 781-786, 2001.
APA
Mutoh, H., Nagata, H., Ohno, K., Numata, T., Nagao, T., Nagao, K., & Konno, A. (2001). Analysis of the p53 gene in parotid gland cancers: a relatively high frequency of mutations in low-grade mucoepidermoid carcinomas. International Journal of Oncology, 18, 781-786. https://doi.org/10.3892/ijo.18.4.781
MLA
Mutoh, H., Nagata, H., Ohno, K., Numata, T., Nagao, T., Nagao, K., Konno, A."Analysis of the p53 gene in parotid gland cancers: a relatively high frequency of mutations in low-grade mucoepidermoid carcinomas". International Journal of Oncology 18.4 (2001): 781-786.
Chicago
Mutoh, H., Nagata, H., Ohno, K., Numata, T., Nagao, T., Nagao, K., Konno, A."Analysis of the p53 gene in parotid gland cancers: a relatively high frequency of mutations in low-grade mucoepidermoid carcinomas". International Journal of Oncology 18, no. 4 (2001): 781-786. https://doi.org/10.3892/ijo.18.4.781
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