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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April 2001 Volume 18 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 2001 Volume 18 Issue 4

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Article

Combinatory anti-tumor effects of electroporation-mediated chemotherapy and wild-type p53 gene transfer to human esophageal cancer cells

  • Authors:
    • Hisahiro Matsubara
    • Tomoko Maeda
    • Yoshio Gunji
    • Yoshio Koide
    • Takehide Asano
    • Takenori Ochiai
    • Shigeru Sakiyama
    • Masatoshi Tagawa

  • View Affiliations / Copyright

    Affiliations: Department of Surgery (II), School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan
  • Pages: 825-829
    |
    Published online on: April 1, 2001
       https://doi.org/10.3892/ijo.18.4.825
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Abstract

Delivery of electric pulses to an established solid tumor augments the permeability of cell membrane and increases the susceptibility of tumors to an anti-cancer agent that is administered in the vicinity of tumors. Forced expression of the wild-type p53 gene in tumor cells that have non-functional p53 gene(s) can also enhance their sensitivity to a DNA-damaging agent. To investigate the feasibility of electroporation-mediated therapy for cancer, electric pulses were delivered to human esophageal tumors developed in nude mice after they received an anti-cancer agent and/or plasmid DNA containing the wild-type p53 gene. The growth of esophageal tumors was suppressed with electroporation-mediated chemotherapy compared with the treatment with an anti-cancer agent or electroporation alone. Intratumoral injection of the wild-type p53 gene into p53-mutated esophageal tumors followed by electroporation also inhibited tumor growth. When mice were administered with the wild-type p53 gene and an anti-cancer agent, subsequent electroporation produced a synergistic therapeutic effect. Combinatory transfer of plasmid DNA and a pharmacological agent by electroporation is thereby a possible therapeutic strategy for the treatment of solid tumors.

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Copy and paste a formatted citation
Spandidos Publications style
Matsubara H, Maeda T, Gunji Y, Koide Y, Asano T, Ochiai T, Sakiyama S and Tagawa M: Combinatory anti-tumor effects of electroporation-mediated chemotherapy and wild-type p53 gene transfer to human esophageal cancer cells. Int J Oncol 18: 825-829, 2001.
APA
Matsubara, H., Maeda, T., Gunji, Y., Koide, Y., Asano, T., Ochiai, T. ... Tagawa, M. (2001). Combinatory anti-tumor effects of electroporation-mediated chemotherapy and wild-type p53 gene transfer to human esophageal cancer cells. International Journal of Oncology, 18, 825-829. https://doi.org/10.3892/ijo.18.4.825
MLA
Matsubara, H., Maeda, T., Gunji, Y., Koide, Y., Asano, T., Ochiai, T., Sakiyama, S., Tagawa, M."Combinatory anti-tumor effects of electroporation-mediated chemotherapy and wild-type p53 gene transfer to human esophageal cancer cells". International Journal of Oncology 18.4 (2001): 825-829.
Chicago
Matsubara, H., Maeda, T., Gunji, Y., Koide, Y., Asano, T., Ochiai, T., Sakiyama, S., Tagawa, M."Combinatory anti-tumor effects of electroporation-mediated chemotherapy and wild-type p53 gene transfer to human esophageal cancer cells". International Journal of Oncology 18, no. 4 (2001): 825-829. https://doi.org/10.3892/ijo.18.4.825
Copy and paste a formatted citation
x
Spandidos Publications style
Matsubara H, Maeda T, Gunji Y, Koide Y, Asano T, Ochiai T, Sakiyama S and Tagawa M: Combinatory anti-tumor effects of electroporation-mediated chemotherapy and wild-type p53 gene transfer to human esophageal cancer cells. Int J Oncol 18: 825-829, 2001.
APA
Matsubara, H., Maeda, T., Gunji, Y., Koide, Y., Asano, T., Ochiai, T. ... Tagawa, M. (2001). Combinatory anti-tumor effects of electroporation-mediated chemotherapy and wild-type p53 gene transfer to human esophageal cancer cells. International Journal of Oncology, 18, 825-829. https://doi.org/10.3892/ijo.18.4.825
MLA
Matsubara, H., Maeda, T., Gunji, Y., Koide, Y., Asano, T., Ochiai, T., Sakiyama, S., Tagawa, M."Combinatory anti-tumor effects of electroporation-mediated chemotherapy and wild-type p53 gene transfer to human esophageal cancer cells". International Journal of Oncology 18.4 (2001): 825-829.
Chicago
Matsubara, H., Maeda, T., Gunji, Y., Koide, Y., Asano, T., Ochiai, T., Sakiyama, S., Tagawa, M."Combinatory anti-tumor effects of electroporation-mediated chemotherapy and wild-type p53 gene transfer to human esophageal cancer cells". International Journal of Oncology 18, no. 4 (2001): 825-829. https://doi.org/10.3892/ijo.18.4.825
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