Combinatory anti-tumor effects of electroporation-mediated chemotherapy and wild-type p53 gene transfer to human esophageal cancer cells

  • Authors:
    • Hisahiro Matsubara
    • Tomoko Maeda
    • Yoshio Gunji
    • Yoshio Koide
    • Takehide Asano
    • Takenori Ochiai
    • Shigeru Sakiyama
    • Masatoshi Tagawa
  • View Affiliations

  • Published online on: April 1, 2001     https://doi.org/10.3892/ijo.18.4.825
  • Pages: 825-829
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Abstract

Delivery of electric pulses to an established solid tumor augments the permeability of cell membrane and increases the susceptibility of tumors to an anti-cancer agent that is administered in the vicinity of tumors. Forced expression of the wild-type p53 gene in tumor cells that have non-functional p53 gene(s) can also enhance their sensitivity to a DNA-damaging agent. To investigate the feasibility of electroporation-mediated therapy for cancer, electric pulses were delivered to human esophageal tumors developed in nude mice after they received an anti-cancer agent and/or plasmid DNA containing the wild-type p53 gene. The growth of esophageal tumors was suppressed with electroporation-mediated chemotherapy compared with the treatment with an anti-cancer agent or electroporation alone. Intratumoral injection of the wild-type p53 gene into p53-mutated esophageal tumors followed by electroporation also inhibited tumor growth. When mice were administered with the wild-type p53 gene and an anti-cancer agent, subsequent electroporation produced a synergistic therapeutic effect. Combinatory transfer of plasmid DNA and a pharmacological agent by electroporation is thereby a possible therapeutic strategy for the treatment of solid tumors.

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April 2001
Volume 18 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Matsubara H, Maeda T, Gunji Y, Koide Y, Asano T, Ochiai T, Sakiyama S and Tagawa M: Combinatory anti-tumor effects of electroporation-mediated chemotherapy and wild-type p53 gene transfer to human esophageal cancer cells. Int J Oncol 18: 825-829, 2001.
APA
Matsubara, H., Maeda, T., Gunji, Y., Koide, Y., Asano, T., Ochiai, T. ... Tagawa, M. (2001). Combinatory anti-tumor effects of electroporation-mediated chemotherapy and wild-type p53 gene transfer to human esophageal cancer cells. International Journal of Oncology, 18, 825-829. https://doi.org/10.3892/ijo.18.4.825
MLA
Matsubara, H., Maeda, T., Gunji, Y., Koide, Y., Asano, T., Ochiai, T., Sakiyama, S., Tagawa, M."Combinatory anti-tumor effects of electroporation-mediated chemotherapy and wild-type p53 gene transfer to human esophageal cancer cells". International Journal of Oncology 18.4 (2001): 825-829.
Chicago
Matsubara, H., Maeda, T., Gunji, Y., Koide, Y., Asano, T., Ochiai, T., Sakiyama, S., Tagawa, M."Combinatory anti-tumor effects of electroporation-mediated chemotherapy and wild-type p53 gene transfer to human esophageal cancer cells". International Journal of Oncology 18, no. 4 (2001): 825-829. https://doi.org/10.3892/ijo.18.4.825