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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April 2001 Volume 18 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 2001 Volume 18 Issue 4

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Article

The interaction between β-catenin, GSK3β and APC after motogen induced cell-cell dissociation, and their involvement in signal transduction pathways in prostate cancer

  • Authors:
    • G. Davies
    • W. G. Jiang
    • M. D. Mason

  • View Affiliations / Copyright

    Affiliations: Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, UK
  • Pages: 843-847
    |
    Published online on: April 1, 2001
       https://doi.org/10.3892/ijo.18.4.843
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Abstract

The effect of HGF/SF was examined on the interactions between APC, GSK3β and β-catenin in prostate cancer cells LNCapFGC (E-cadherin positive) and PC-3 (E-cadherin negative). Using immunoprecipitation, APC was found to be co-precipitated with either GSK3β or β-catenin in both cell lines. Stimulation with HGF/SF showed no change in the co-precipitation status of these protein molecules. In contrast, co-precipitation between GSK3β and β-catenin was only observed in LNCapFGC cells, and increased upon continued exposure to the motogen HGF/SF. Furthermore, using immunofluorescence, stimulation with HGF/SF was found to increase the level of co-localised cytoplasmic staining between β-catenin and GSK3β, in prostate cancer cells. RT-PCR revealed that there were no mutations within the binding regions between β-catenin and GSK3β. It is concluded, that uncomplexed cytoplasmic pools of β-catenin associate more readily with the Axin complex in the absence of E-cadherin. Whereas, in the presence of E-cadherin, β-catenin is stabilised by forming tight cell-cell contacts which may influence the invasive potential of cancer cells.

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Copy and paste a formatted citation
Spandidos Publications style
Davies G, Jiang WG and Mason MD: The interaction between β-catenin, GSK3β and APC after motogen induced cell-cell dissociation, and their involvement in signal transduction pathways in prostate cancer. Int J Oncol 18: 843-847, 2001.
APA
Davies, G., Jiang, W.G., & Mason, M.D. (2001). The interaction between β-catenin, GSK3β and APC after motogen induced cell-cell dissociation, and their involvement in signal transduction pathways in prostate cancer. International Journal of Oncology, 18, 843-847. https://doi.org/10.3892/ijo.18.4.843
MLA
Davies, G., Jiang, W. G., Mason, M. D."The interaction between β-catenin, GSK3β and APC after motogen induced cell-cell dissociation, and their involvement in signal transduction pathways in prostate cancer". International Journal of Oncology 18.4 (2001): 843-847.
Chicago
Davies, G., Jiang, W. G., Mason, M. D."The interaction between β-catenin, GSK3β and APC after motogen induced cell-cell dissociation, and their involvement in signal transduction pathways in prostate cancer". International Journal of Oncology 18, no. 4 (2001): 843-847. https://doi.org/10.3892/ijo.18.4.843
Copy and paste a formatted citation
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Spandidos Publications style
Davies G, Jiang WG and Mason MD: The interaction between β-catenin, GSK3β and APC after motogen induced cell-cell dissociation, and their involvement in signal transduction pathways in prostate cancer. Int J Oncol 18: 843-847, 2001.
APA
Davies, G., Jiang, W.G., & Mason, M.D. (2001). The interaction between β-catenin, GSK3β and APC after motogen induced cell-cell dissociation, and their involvement in signal transduction pathways in prostate cancer. International Journal of Oncology, 18, 843-847. https://doi.org/10.3892/ijo.18.4.843
MLA
Davies, G., Jiang, W. G., Mason, M. D."The interaction between β-catenin, GSK3β and APC after motogen induced cell-cell dissociation, and their involvement in signal transduction pathways in prostate cancer". International Journal of Oncology 18.4 (2001): 843-847.
Chicago
Davies, G., Jiang, W. G., Mason, M. D."The interaction between β-catenin, GSK3β and APC after motogen induced cell-cell dissociation, and their involvement in signal transduction pathways in prostate cancer". International Journal of Oncology 18, no. 4 (2001): 843-847. https://doi.org/10.3892/ijo.18.4.843
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