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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April 2001 Volume 18 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 2001 Volume 18 Issue 4

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Article

Overexpression of platelet-derived growth factor B and downregulation of PDGF-receptor α in human immortalized fibroblasts

  • Authors:
    • Chong Gao
    • Masahiro Miyazaki
    • Tadashi Kondo
    • Toshiya Tsuji
    • Masakiyo Sakaguchi
    • Masayoshi Namba

  • View Affiliations / Copyright

    Affiliations: Department of Cell Biology, Institute of Cellular and Molecular Biology, Okayama University Medical School, Okayama 700-8558, Japan
  • Pages: 871-875
    |
    Published online on: April 1, 2001
       https://doi.org/10.3892/ijo.18.4.871
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Abstract

Since immortalization of cells is critical in multistep carcinogenesis, efforts should be made to elucidate the mechanisms of the immortalization. To determine whether platelet-derived growth factor (PDGF) signal pathways play a role in immortalization of cells, we compared mRNA expressions of PDGFs and their receptors in three immortalized human fibroblast cell lines (SUSM-1, OUMS-24F, and KMST-6) with their normal parent cells. As a result, mRNA expression of PDGF-B (oncogene: c-sis) was upregulated in these immortalized cells. Unexpectedly, the expression of α- and β-PDGF receptor genes was downregulated. PDGFR-α mRNA was remarkably decreased. When exogenous PDGFR-α was expressed transiently in the KMST-6 cells, the morphology of the cells resembled that of normal cells. These results suggest that the overexpression of PDGF-B (c-sis) and downregulation of PDGFR-α are related to the phenotypic characteristics of immortalized human cells.

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Copy and paste a formatted citation
Spandidos Publications style
Gao C, Miyazaki M, Kondo T, Tsuji T, Sakaguchi M and Namba M: Overexpression of platelet-derived growth factor B and downregulation of PDGF-receptor α in human immortalized fibroblasts. Int J Oncol 18: 871-875, 2001.
APA
Gao, C., Miyazaki, M., Kondo, T., Tsuji, T., Sakaguchi, M., & Namba, M. (2001). Overexpression of platelet-derived growth factor B and downregulation of PDGF-receptor α in human immortalized fibroblasts. International Journal of Oncology, 18, 871-875. https://doi.org/10.3892/ijo.18.4.871
MLA
Gao, C., Miyazaki, M., Kondo, T., Tsuji, T., Sakaguchi, M., Namba, M."Overexpression of platelet-derived growth factor B and downregulation of PDGF-receptor α in human immortalized fibroblasts". International Journal of Oncology 18.4 (2001): 871-875.
Chicago
Gao, C., Miyazaki, M., Kondo, T., Tsuji, T., Sakaguchi, M., Namba, M."Overexpression of platelet-derived growth factor B and downregulation of PDGF-receptor α in human immortalized fibroblasts". International Journal of Oncology 18, no. 4 (2001): 871-875. https://doi.org/10.3892/ijo.18.4.871
Copy and paste a formatted citation
x
Spandidos Publications style
Gao C, Miyazaki M, Kondo T, Tsuji T, Sakaguchi M and Namba M: Overexpression of platelet-derived growth factor B and downregulation of PDGF-receptor α in human immortalized fibroblasts. Int J Oncol 18: 871-875, 2001.
APA
Gao, C., Miyazaki, M., Kondo, T., Tsuji, T., Sakaguchi, M., & Namba, M. (2001). Overexpression of platelet-derived growth factor B and downregulation of PDGF-receptor α in human immortalized fibroblasts. International Journal of Oncology, 18, 871-875. https://doi.org/10.3892/ijo.18.4.871
MLA
Gao, C., Miyazaki, M., Kondo, T., Tsuji, T., Sakaguchi, M., Namba, M."Overexpression of platelet-derived growth factor B and downregulation of PDGF-receptor α in human immortalized fibroblasts". International Journal of Oncology 18.4 (2001): 871-875.
Chicago
Gao, C., Miyazaki, M., Kondo, T., Tsuji, T., Sakaguchi, M., Namba, M."Overexpression of platelet-derived growth factor B and downregulation of PDGF-receptor α in human immortalized fibroblasts". International Journal of Oncology 18, no. 4 (2001): 871-875. https://doi.org/10.3892/ijo.18.4.871
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