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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 2001 Volume 18 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2001 Volume 18 Issue 6

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Article

Central and ambivalent role of hydrogen peroxide during intercellular induction of apoptosis

  • Authors:
    • Katja Von Eynatten
    • Georg Bauer

  • View Affiliations / Copyright

    Affiliations: Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, Freiburg, Cermany
  • Pages: 1169-1174
    |
    Published online on: June 1, 2001
       https://doi.org/10.3892/ijo.18.6.1169
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Abstract

TGF-β pretreated non-transformed fibroblasts induce apoptosis selectively in transformed fibroblasts. This novel potential control step of oncogenesis has been termed intercellular induction of apoptosis. Intercellular signalling depends on target cell-derived extracellular superoxide anions that drive the efficiency of two signalling pathways. These are based on the formation of peroxynitrite through nitric oxide/superoxide anion interaction and on the generation of hypochlorous acid, followed by interaction of hypochlorous acid with superoxide anions, leading to the generation of hydroxyl radicals. This report demonstrates that exogenous hydrogen peroxide causes an overall inhibition of intercellular induction of apoptosis through blunting of the nitric oxide/peroxynitrite signalling pathway. When the HOCl/hydroxyl radical signalling pathway is studied separately (in the presence of an inhibitor of nitric oxide synthesis), exogenous hydrogen peroxide causes an enhancement of apoptosis induction. Based on the dual and adverse effects of hydrogen peroxide on intercellular induction of apoptosis, its steady state concentration seems to be one of the critical parameters that determine efficiency of apoptosis induction in transformed cells.

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Spandidos Publications style
Von Eynatten K and Bauer G: Central and ambivalent role of hydrogen peroxide during intercellular induction of apoptosis. Int J Oncol 18: 1169-1174, 2001.
APA
Von Eynatten, K., & Bauer, G. (2001). Central and ambivalent role of hydrogen peroxide during intercellular induction of apoptosis. International Journal of Oncology, 18, 1169-1174. https://doi.org/10.3892/ijo.18.6.1169
MLA
Von Eynatten, K., Bauer, G."Central and ambivalent role of hydrogen peroxide during intercellular induction of apoptosis". International Journal of Oncology 18.6 (2001): 1169-1174.
Chicago
Von Eynatten, K., Bauer, G."Central and ambivalent role of hydrogen peroxide during intercellular induction of apoptosis". International Journal of Oncology 18, no. 6 (2001): 1169-1174. https://doi.org/10.3892/ijo.18.6.1169
Copy and paste a formatted citation
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Spandidos Publications style
Von Eynatten K and Bauer G: Central and ambivalent role of hydrogen peroxide during intercellular induction of apoptosis. Int J Oncol 18: 1169-1174, 2001.
APA
Von Eynatten, K., & Bauer, G. (2001). Central and ambivalent role of hydrogen peroxide during intercellular induction of apoptosis. International Journal of Oncology, 18, 1169-1174. https://doi.org/10.3892/ijo.18.6.1169
MLA
Von Eynatten, K., Bauer, G."Central and ambivalent role of hydrogen peroxide during intercellular induction of apoptosis". International Journal of Oncology 18.6 (2001): 1169-1174.
Chicago
Von Eynatten, K., Bauer, G."Central and ambivalent role of hydrogen peroxide during intercellular induction of apoptosis". International Journal of Oncology 18, no. 6 (2001): 1169-1174. https://doi.org/10.3892/ijo.18.6.1169
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