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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 2001 Volume 19 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2001 Volume 19 Issue 1

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Article

Up-regulation of Frizzled-7 (FZD7) in human gastric cancer

  • Authors:
    • Hiroyuki Kirikoshi
    • Hisahiko Sekihara
    • Masaru Katoh
  • View Affiliations / Copyright

    Affiliations: Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tokyo 104-0045, Japan
  • Pages: 111-115
    |
    Published online on: July 1, 2001
       https://doi.org/10.3892/ijo.19.1.111
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Abstract

Human Frizzled-7 (FZD7) and human FzE3, showing 98.8% nucleotide identity, encode almost identical WNT receptors with nine amino-acid substitutions. FzE3 is claimed to be expressed specifically in esophageal cancer. We determined the structure of the FZD7 gene and the FZD7 cDNA expressed in esophageal cancer. The FZD7 gene without intron and the FZD7 cDNAs isolated from esophageal cancer cell lines TE4 and TE5 were found to encode WNT receptor identical to FZD7, but not to FzE3. Nucleotide sequence of FzE3 was not identified on the human genome draft sequence. Thus, we could not obtain any data suggesting the existence of FzE3. Expression profile of FZD7 was also investigated. FZD7 was expressed throughout normal gastrointestinal tract, from esophagus to rectum. Among human esophageal and gastric cancer cell lines, expression level of FZD7 was relatively lower in esophageal cancer cell lines, and was highest in the gastric cancer cell line MKN7. FZD7 was up-regulated in one out of six cases of human primary gastric cancer. As over-expression of Frizzled-7 leads to activation of the WNT-β-catenin-TCF pathway, up-regulation of FZD7 in human gastric cancer might play key roles in carcinogenesis through activation of the WNT-β-catenin-TCF pathway.

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Copy and paste a formatted citation
Spandidos Publications style
Kirikoshi H, Sekihara H and Katoh M: Up-regulation of Frizzled-7 (FZD7) in human gastric cancer. Int J Oncol 19: 111-115, 2001.
APA
Kirikoshi, H., Sekihara, H., & Katoh, M. (2001). Up-regulation of Frizzled-7 (FZD7) in human gastric cancer. International Journal of Oncology, 19, 111-115. https://doi.org/10.3892/ijo.19.1.111
MLA
Kirikoshi, H., Sekihara, H., Katoh, M."Up-regulation of Frizzled-7 (FZD7) in human gastric cancer". International Journal of Oncology 19.1 (2001): 111-115.
Chicago
Kirikoshi, H., Sekihara, H., Katoh, M."Up-regulation of Frizzled-7 (FZD7) in human gastric cancer". International Journal of Oncology 19, no. 1 (2001): 111-115. https://doi.org/10.3892/ijo.19.1.111
Copy and paste a formatted citation
x
Spandidos Publications style
Kirikoshi H, Sekihara H and Katoh M: Up-regulation of Frizzled-7 (FZD7) in human gastric cancer. Int J Oncol 19: 111-115, 2001.
APA
Kirikoshi, H., Sekihara, H., & Katoh, M. (2001). Up-regulation of Frizzled-7 (FZD7) in human gastric cancer. International Journal of Oncology, 19, 111-115. https://doi.org/10.3892/ijo.19.1.111
MLA
Kirikoshi, H., Sekihara, H., Katoh, M."Up-regulation of Frizzled-7 (FZD7) in human gastric cancer". International Journal of Oncology 19.1 (2001): 111-115.
Chicago
Kirikoshi, H., Sekihara, H., Katoh, M."Up-regulation of Frizzled-7 (FZD7) in human gastric cancer". International Journal of Oncology 19, no. 1 (2001): 111-115. https://doi.org/10.3892/ijo.19.1.111
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