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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August 2001 Volume 19 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2001 Volume 19 Issue 2

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Article

Hypermethylation of p16INK4a and p15INK4b genes in non-small cell lung cancer

  • Authors:
    • Eri Kurakawa
    • Takashi Shimamoto
    • Kenta Utsumi
    • Takashi Hirano
    • Harubumi Kato
    • Kazuma Ohyashiki

  • View Affiliations

    Affiliations: First Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan
  • Published online on: August 1, 2001     https://doi.org/10.3892/ijo.19.2.277
  • Pages: 277-281
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Abstract

Hypermethylation of CpG island is a common mechanism by which tumor suppressor genes are inactivated. The tumor suppressor genes p16INK4a and p15INK4b are important components of the cell cycles. We have studied the feasibility of detecting tumor-associated aberrant p16INK4a and p15INK4b methylation in non-small cell lung cancer (NSCLC) using methylation-specific PCR. We found a high frequency of hypermethylation of the p16INK4a gene in 17 of 45 cases of NSCLC. In this study, there was no difference between the clinicopathological features or overall survival of patients with and without p16INK4a methylation. On the other hand, p15INK4b promoter hypermethylation is rare (5/45) in lung cancer and occurs in association with p16INK4a methylation. The overall survival of patients with p15INK4b methylation was markedly shortened in this series. We also analyzed cells in bronchial washings, and p16INK4a methylation was detected in 4 of 17 cases of NSCLC. Moreover, 1 of 10 plasma samples from patients with NSCLC was positive for p16INK4a methylation. Our results suggest a possible prognostic role of p15INK4b methylation in NSCLC, and that the detection of aberrant p16INK4a methylation in both bronchial washings and plasma may be useful for cancer diagnosis.

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Copy and paste a formatted citation
Spandidos Publications style
Kurakawa E, Shimamoto T, Utsumi K, Hirano T, Kato H and Ohyashiki K: Hypermethylation of p16INK4a and p15INK4b genes in non-small cell lung cancer. Int J Oncol 19: 277-281, 2001.
APA
Kurakawa, E., Shimamoto, T., Utsumi, K., Hirano, T., Kato, H., & Ohyashiki, K. (2001). Hypermethylation of p16INK4a and p15INK4b genes in non-small cell lung cancer. International Journal of Oncology, 19, 277-281. https://doi.org/10.3892/ijo.19.2.277
MLA
Kurakawa, E., Shimamoto, T., Utsumi, K., Hirano, T., Kato, H., Ohyashiki, K."Hypermethylation of p16INK4a and p15INK4b genes in non-small cell lung cancer". International Journal of Oncology 19.2 (2001): 277-281.
Chicago
Kurakawa, E., Shimamoto, T., Utsumi, K., Hirano, T., Kato, H., Ohyashiki, K."Hypermethylation of p16INK4a and p15INK4b genes in non-small cell lung cancer". International Journal of Oncology 19, no. 2 (2001): 277-281. https://doi.org/10.3892/ijo.19.2.277
Copy and paste a formatted citation
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Spandidos Publications style
Kurakawa E, Shimamoto T, Utsumi K, Hirano T, Kato H and Ohyashiki K: Hypermethylation of p16INK4a and p15INK4b genes in non-small cell lung cancer. Int J Oncol 19: 277-281, 2001.
APA
Kurakawa, E., Shimamoto, T., Utsumi, K., Hirano, T., Kato, H., & Ohyashiki, K. (2001). Hypermethylation of p16INK4a and p15INK4b genes in non-small cell lung cancer. International Journal of Oncology, 19, 277-281. https://doi.org/10.3892/ijo.19.2.277
MLA
Kurakawa, E., Shimamoto, T., Utsumi, K., Hirano, T., Kato, H., Ohyashiki, K."Hypermethylation of p16INK4a and p15INK4b genes in non-small cell lung cancer". International Journal of Oncology 19.2 (2001): 277-281.
Chicago
Kurakawa, E., Shimamoto, T., Utsumi, K., Hirano, T., Kato, H., Ohyashiki, K."Hypermethylation of p16INK4a and p15INK4b genes in non-small cell lung cancer". International Journal of Oncology 19, no. 2 (2001): 277-281. https://doi.org/10.3892/ijo.19.2.277
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