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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August 2001 Volume 19 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2001 Volume 19 Issue 2

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Article

Selective apoptosis induction in transformed fibroblasts by B cell lines: involvement of reactive oxygen and nitrogen species

  • Authors:
    • Mareike Schimmel
    • Georg Bauer

  • View Affiliations / Copyright

    Affiliations: Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, Freiburg, Germany
  • Pages: 299-304
    |
    Published online on: August 1, 2001
       https://doi.org/10.3892/ijo.19.2.299
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Abstract

B cell lines induce apoptosis selectively in transformed fibroblasts. Apoptosis induction is independent of direct cell contact. It seems to be based on superoxide anion production by transformed cells, subsequent spontaneous dismutation to hydrogen peroxide and utilization of the hydrogen peroxide by a peroxidase released by effector cells. The peroxidase then generates hypochlorous acid which may interact with target cell derived superoxide anions, yielding apoptosis-inducing hydroxyl radicals. In parallel, NO released by effector cells may interact with target cell derived superoxide anions and generate the apoptosis inducer peroxynitrite. Therefore, in parallel to their specific functions in humoral immunity, B cells seem to have the potential to contribute to those signalling pathways directed against transformed cells that have been recently shown to be established by TGF-β treated fibroblasts. This intercellular signalling system seems to represent an evolutionary ancient system for the control of cells that potentially endanger the survival of multicellular organisms.

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Spandidos Publications style
Schimmel M and Bauer G: Selective apoptosis induction in transformed fibroblasts by B cell lines: involvement of reactive oxygen and nitrogen species. Int J Oncol 19: 299-304, 2001.
APA
Schimmel, M., & Bauer, G. (2001). Selective apoptosis induction in transformed fibroblasts by B cell lines: involvement of reactive oxygen and nitrogen species. International Journal of Oncology, 19, 299-304. https://doi.org/10.3892/ijo.19.2.299
MLA
Schimmel, M., Bauer, G."Selective apoptosis induction in transformed fibroblasts by B cell lines: involvement of reactive oxygen and nitrogen species". International Journal of Oncology 19.2 (2001): 299-304.
Chicago
Schimmel, M., Bauer, G."Selective apoptosis induction in transformed fibroblasts by B cell lines: involvement of reactive oxygen and nitrogen species". International Journal of Oncology 19, no. 2 (2001): 299-304. https://doi.org/10.3892/ijo.19.2.299
Copy and paste a formatted citation
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Spandidos Publications style
Schimmel M and Bauer G: Selective apoptosis induction in transformed fibroblasts by B cell lines: involvement of reactive oxygen and nitrogen species. Int J Oncol 19: 299-304, 2001.
APA
Schimmel, M., & Bauer, G. (2001). Selective apoptosis induction in transformed fibroblasts by B cell lines: involvement of reactive oxygen and nitrogen species. International Journal of Oncology, 19, 299-304. https://doi.org/10.3892/ijo.19.2.299
MLA
Schimmel, M., Bauer, G."Selective apoptosis induction in transformed fibroblasts by B cell lines: involvement of reactive oxygen and nitrogen species". International Journal of Oncology 19.2 (2001): 299-304.
Chicago
Schimmel, M., Bauer, G."Selective apoptosis induction in transformed fibroblasts by B cell lines: involvement of reactive oxygen and nitrogen species". International Journal of Oncology 19, no. 2 (2001): 299-304. https://doi.org/10.3892/ijo.19.2.299
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