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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August 2001 Volume 19 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2001 Volume 19 Issue 2

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Article

FRAT1 and FRAT2, clustered in human chromosome 10q24.1 region, are up-regulated in gastric cancer

  • Authors:
    • Tetsuroh Saitoh
    • Masaru Katoh

  • View Affiliations / Copyright

    Affiliations: Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tokyo 104-0045, Japan
  • Pages: 311-315
    |
    Published online on: August 1, 2001
       https://doi.org/10.3892/ijo.19.2.311
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Abstract

FRAT1 and FRAT2 are cancer-associated genes encoding GSK-3β-binding proteins. Over-expression of FRAT1 or FRAT2 lead to carcinogenesis through activation of WNT - β-catenin - TCF signaling pathway. We have previously cloned and characterized FRAT2. Here, we found that FRAT1 and FRAT2 genes were clustered in the human chromosome 10q24.1 region. Blast search revealed that FRAT1 and FRAT2 genes, consisting of a single exon, were located together on human genome draft sequences AC006098.1 and AL355490.7, corresponding to the human chromosome 10q24.1 region. FRAT1 and FRAT2 genes were clustered in a tail to tail manner with an interval of about 10.7 kb. The 2.7-kb FRAT1 mRNA was relatively highly expressed in fetal brain, adult spleen, pancreas, HeLa S3 (cervical cancer), and K-562 (chronic myelogenous leukemia). FRAT1 and FRAT2 were co-expressed in 7 gastric cancer cell lines and 10 cases of primary gastric cancer, and were up-regulated together in gastric cancer cell line TMK1 and 2 cases of primary gastric cancer. These results indicated that FRAT1 and FRAT2 genes were up-regulated together in several cases of human gastric cancer. Up-regulation of FRAT1 and FRAT2 in gastric cancer might lead to carcinogenesis through activation of WNT - β-catenin - TCF signaling pathway.

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Copy and paste a formatted citation
Spandidos Publications style
Saitoh T and Katoh M: FRAT1 and FRAT2, clustered in human chromosome 10q24.1 region, are up-regulated in gastric cancer. Int J Oncol 19: 311-315, 2001.
APA
Saitoh, T., & Katoh, M. (2001). FRAT1 and FRAT2, clustered in human chromosome 10q24.1 region, are up-regulated in gastric cancer. International Journal of Oncology, 19, 311-315. https://doi.org/10.3892/ijo.19.2.311
MLA
Saitoh, T., Katoh, M."FRAT1 and FRAT2, clustered in human chromosome 10q24.1 region, are up-regulated in gastric cancer". International Journal of Oncology 19.2 (2001): 311-315.
Chicago
Saitoh, T., Katoh, M."FRAT1 and FRAT2, clustered in human chromosome 10q24.1 region, are up-regulated in gastric cancer". International Journal of Oncology 19, no. 2 (2001): 311-315. https://doi.org/10.3892/ijo.19.2.311
Copy and paste a formatted citation
x
Spandidos Publications style
Saitoh T and Katoh M: FRAT1 and FRAT2, clustered in human chromosome 10q24.1 region, are up-regulated in gastric cancer. Int J Oncol 19: 311-315, 2001.
APA
Saitoh, T., & Katoh, M. (2001). FRAT1 and FRAT2, clustered in human chromosome 10q24.1 region, are up-regulated in gastric cancer. International Journal of Oncology, 19, 311-315. https://doi.org/10.3892/ijo.19.2.311
MLA
Saitoh, T., Katoh, M."FRAT1 and FRAT2, clustered in human chromosome 10q24.1 region, are up-regulated in gastric cancer". International Journal of Oncology 19.2 (2001): 311-315.
Chicago
Saitoh, T., Katoh, M."FRAT1 and FRAT2, clustered in human chromosome 10q24.1 region, are up-regulated in gastric cancer". International Journal of Oncology 19, no. 2 (2001): 311-315. https://doi.org/10.3892/ijo.19.2.311
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