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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August 2001 Volume 19 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2001 Volume 19 Issue 2

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Article

Differential expression of the multidrug resistance-related protein MRP1 in the histological compartments of nephroblastomas

  • Authors:
    • Thomas Efferth
    • Paul Thelen
    • Hans-Gunther Schulten
    • Marc-Eric Bode
    • Bernd Granzen
    • Antonius J.M.C. Beniers
    • Rolf Mertens
    • Rolf-Hermann Ringert
    • Olaf Gefeller
    • Gerd Jakse
    • Laszlo Fuzesi

  • View Affiliations / Copyright

    Affiliations: Virtual Campus Rhineland-Palatinate, G-55033 Mainz, Germany
  • Pages: 367-371
    |
    Published online on: August 1, 2001
       https://doi.org/10.3892/ijo.19.2.367
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Abstract

Nephroblastomas (Wilms' tumors) are curable with survival rates above 80%. Some tumors, however, fail to respond to therapy and those patients have a poor prognosis. In a search for prognostic markers, we investigated the expression of the multidrug resistance-related protein 1 (MRP1) in 32 nephroblastomas by means of immunohistochemistry. The immunohistochemical results were validated with a real-time RT-PCR technique. MRP1 expression was heterogeneous and predominately found in the blastemal and epithelial compartments compared to the stromal elements of nephroblastomas. We found significant relationships of MRP1 expression to survival of patients and to expression of p53, HSP70, and LRP/MVP. The relationship between MRP1 and p53 expression is a clue that the transcriptional control of MRP1 by p53 reported for other tumor types may also take place in nephroblastomas. The correlation of MRP1 to other drug resistance genes, e.g. HSP70 and LRP/MVP in nephroblastomas indicates that the co-expression of different drug resistance genes may be under a common regulation of still unknown transcription factors.

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Copy and paste a formatted citation
Spandidos Publications style
Efferth T, Thelen P, Schulten H, Bode M, Granzen B, Beniers AJ, Mertens R, Ringert R, Gefeller O, Jakse G, Jakse G, et al: Differential expression of the multidrug resistance-related protein MRP1 in the histological compartments of nephroblastomas. Int J Oncol 19: 367-371, 2001.
APA
Efferth, T., Thelen, P., Schulten, H., Bode, M., Granzen, B., Beniers, A.J. ... Fuzesi, L. (2001). Differential expression of the multidrug resistance-related protein MRP1 in the histological compartments of nephroblastomas. International Journal of Oncology, 19, 367-371. https://doi.org/10.3892/ijo.19.2.367
MLA
Efferth, T., Thelen, P., Schulten, H., Bode, M., Granzen, B., Beniers, A. J., Mertens, R., Ringert, R., Gefeller, O., Jakse, G., Fuzesi, L."Differential expression of the multidrug resistance-related protein MRP1 in the histological compartments of nephroblastomas". International Journal of Oncology 19.2 (2001): 367-371.
Chicago
Efferth, T., Thelen, P., Schulten, H., Bode, M., Granzen, B., Beniers, A. J., Mertens, R., Ringert, R., Gefeller, O., Jakse, G., Fuzesi, L."Differential expression of the multidrug resistance-related protein MRP1 in the histological compartments of nephroblastomas". International Journal of Oncology 19, no. 2 (2001): 367-371. https://doi.org/10.3892/ijo.19.2.367
Copy and paste a formatted citation
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Spandidos Publications style
Efferth T, Thelen P, Schulten H, Bode M, Granzen B, Beniers AJ, Mertens R, Ringert R, Gefeller O, Jakse G, Jakse G, et al: Differential expression of the multidrug resistance-related protein MRP1 in the histological compartments of nephroblastomas. Int J Oncol 19: 367-371, 2001.
APA
Efferth, T., Thelen, P., Schulten, H., Bode, M., Granzen, B., Beniers, A.J. ... Fuzesi, L. (2001). Differential expression of the multidrug resistance-related protein MRP1 in the histological compartments of nephroblastomas. International Journal of Oncology, 19, 367-371. https://doi.org/10.3892/ijo.19.2.367
MLA
Efferth, T., Thelen, P., Schulten, H., Bode, M., Granzen, B., Beniers, A. J., Mertens, R., Ringert, R., Gefeller, O., Jakse, G., Fuzesi, L."Differential expression of the multidrug resistance-related protein MRP1 in the histological compartments of nephroblastomas". International Journal of Oncology 19.2 (2001): 367-371.
Chicago
Efferth, T., Thelen, P., Schulten, H., Bode, M., Granzen, B., Beniers, A. J., Mertens, R., Ringert, R., Gefeller, O., Jakse, G., Fuzesi, L."Differential expression of the multidrug resistance-related protein MRP1 in the histological compartments of nephroblastomas". International Journal of Oncology 19, no. 2 (2001): 367-371. https://doi.org/10.3892/ijo.19.2.367
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