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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 2001 Volume 19 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2001 Volume 19 Issue 3

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Article

Microsatellite alterations in human hepatocellular carcinoma infected with hepatitis B virus: Associated with the elevation of serum α-fetoprotein

  • Authors:
    • Er-Bin Yang
    • Yin-Nong Zhao
    • Kai Zhang
    • Peter Mack

  • View Affiliations / Copyright

    Affiliations: Department of Experimental Surgery, Singapore General Hospital, Singapore 169608
  • Pages: 513-518
    |
    Published online on: September 1, 2001
       https://doi.org/10.3892/ijo.19.3.513
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Abstract

Identification of the basic genetic changes in human hepatocellular carcinoma (HCC) is very important for the understanding of this cancer. In this study, genomic DNA from 29 pairs of HCC and corresponding non-tumour tissues infected with hepatitis B virus (HBV) was prepared. Five CA-repeated microsatellite markers, including D8S277, D3S1029, D5S409, D2S123, and TP53, were used to analyse microsatellite alterations and their subtypes in these patients by polymerase chain reaction (PCR) amplification and denatured polyacrylamide gel electrophoresis. Microsatellite alterations were found in 15 of the 29 HCC patients (51.72%), implying that microsatellites are unstable in genomic DNA of HBV-infected HCC. It was found that frequency of microsatellite alterations in these HCC patients was not associated with patients' age, sex, status of tumour differentiation, and tumour size. Frequency of microsatellite alterations in HCC patients with cirrhosis tended to be less than that in patients without cirrhosis, but Fisher's exact test, 2-tailed, showed that this difference was not significant. Significantly more microsatellite alterations in serum α-fetoprotein (AFP)-positive cases were observed than those in serum AFP-negative ones, implying that the elevation of AFP in HBV-infected HCC may be associated with microsatellite stability.

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Copy and paste a formatted citation
Spandidos Publications style
Yang E, Zhao Y, Zhang K and Mack P: Microsatellite alterations in human hepatocellular carcinoma infected with hepatitis B virus: Associated with the elevation of serum α-fetoprotein. Int J Oncol 19: 513-518, 2001.
APA
Yang, E., Zhao, Y., Zhang, K., & Mack, P. (2001). Microsatellite alterations in human hepatocellular carcinoma infected with hepatitis B virus: Associated with the elevation of serum α-fetoprotein. International Journal of Oncology, 19, 513-518. https://doi.org/10.3892/ijo.19.3.513
MLA
Yang, E., Zhao, Y., Zhang, K., Mack, P."Microsatellite alterations in human hepatocellular carcinoma infected with hepatitis B virus: Associated with the elevation of serum α-fetoprotein". International Journal of Oncology 19.3 (2001): 513-518.
Chicago
Yang, E., Zhao, Y., Zhang, K., Mack, P."Microsatellite alterations in human hepatocellular carcinoma infected with hepatitis B virus: Associated with the elevation of serum α-fetoprotein". International Journal of Oncology 19, no. 3 (2001): 513-518. https://doi.org/10.3892/ijo.19.3.513
Copy and paste a formatted citation
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Spandidos Publications style
Yang E, Zhao Y, Zhang K and Mack P: Microsatellite alterations in human hepatocellular carcinoma infected with hepatitis B virus: Associated with the elevation of serum α-fetoprotein. Int J Oncol 19: 513-518, 2001.
APA
Yang, E., Zhao, Y., Zhang, K., & Mack, P. (2001). Microsatellite alterations in human hepatocellular carcinoma infected with hepatitis B virus: Associated with the elevation of serum α-fetoprotein. International Journal of Oncology, 19, 513-518. https://doi.org/10.3892/ijo.19.3.513
MLA
Yang, E., Zhao, Y., Zhang, K., Mack, P."Microsatellite alterations in human hepatocellular carcinoma infected with hepatitis B virus: Associated with the elevation of serum α-fetoprotein". International Journal of Oncology 19.3 (2001): 513-518.
Chicago
Yang, E., Zhao, Y., Zhang, K., Mack, P."Microsatellite alterations in human hepatocellular carcinoma infected with hepatitis B virus: Associated with the elevation of serum α-fetoprotein". International Journal of Oncology 19, no. 3 (2001): 513-518. https://doi.org/10.3892/ijo.19.3.513
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