Up-regulation of WNT10A by tumor necrosis factor α and Helicobacter pylori in gastric cancer

  • Authors:
    • Hiroyuki Kirikoshi
    • Hisahiko Sekihara
    • Masaru Katoh
  • View Affiliations

  • Published online on: September 1, 2001     https://doi.org/10.3892/ijo.19.3.533
  • Pages: 533-536
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

WNT signaling pathway is implicated in carcinogenesis and embryogenesis. We have previously cloned and characterized WNT10A and WNT6, which are clustered in human chromosome 2q35 region. In this study, we investigated expression of WNT10A and WNT6 in gastric cancer. The 3.0- and 2.4-kb WNT10A mRNAs were expressed in gastric cancer cell lines MKN7, MKN45 and MKN74. The 2.0-kb WNT6 mRNA was expressed in gastric cancer cell lines MKN28 and MKN74. WNT10A was up-regulated in 3 out of 6 cases of primary gastric cancer, while WNT6 was not up-regulated in primary gastric cancer. Effects of inflammatory cytokines and Helicobacter pylori (H. pylori) on expression of WNT10A and WNT6 were next investigated. Interferon γ (IFNγ) failed to induce up-regulation of WNT10A and WNT6. Tumor necrosis factor α (TNFα) induced up-regulation of WNT10A in MKN45 cells. Up-regulation of WNT10A reached maximum at 6 h after TNFα treatment. H. pylori also induced up-regulation of WNT10A in MKN45 cells. These results strongly suggest that up-regulation of WNT10A induced by TNFα and H. pylori might play key roles in human gastric cancer through activation of WNT - β-catenin - TCF signaling pathway.

Related Articles

Journal Cover

September 2001
Volume 19 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Kirikoshi H, Sekihara H and Katoh M: Up-regulation of WNT10A by tumor necrosis factor α and Helicobacter pylori in gastric cancer. Int J Oncol 19: 533-536, 2001
APA
Kirikoshi, H., Sekihara, H., & Katoh, M. (2001). Up-regulation of WNT10A by tumor necrosis factor α and Helicobacter pylori in gastric cancer. International Journal of Oncology, 19, 533-536. https://doi.org/10.3892/ijo.19.3.533
MLA
Kirikoshi, H., Sekihara, H., Katoh, M."Up-regulation of WNT10A by tumor necrosis factor α and Helicobacter pylori in gastric cancer". International Journal of Oncology 19.3 (2001): 533-536.
Chicago
Kirikoshi, H., Sekihara, H., Katoh, M."Up-regulation of WNT10A by tumor necrosis factor α and Helicobacter pylori in gastric cancer". International Journal of Oncology 19, no. 3 (2001): 533-536. https://doi.org/10.3892/ijo.19.3.533