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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 2001 Volume 19 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2001 Volume 19 Issue 3

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Article

Up-regulation of WNT10A by tumor necrosis factor α and Helicobacter pylori in gastric cancer

  • Authors:
    • Hiroyuki Kirikoshi
    • Hisahiko Sekihara
    • Masaru Katoh

  • View Affiliations / Copyright

    Affiliations: Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute,Tokyo 104-0045, Japan
  • Pages: 533-536
    |
    Published online on: September 1, 2001
       https://doi.org/10.3892/ijo.19.3.533
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Abstract

WNT signaling pathway is implicated in carcinogenesis and embryogenesis. We have previously cloned and characterized WNT10A and WNT6, which are clustered in human chromosome 2q35 region. In this study, we investigated expression of WNT10A and WNT6 in gastric cancer. The 3.0- and 2.4-kb WNT10A mRNAs were expressed in gastric cancer cell lines MKN7, MKN45 and MKN74. The 2.0-kb WNT6 mRNA was expressed in gastric cancer cell lines MKN28 and MKN74. WNT10A was up-regulated in 3 out of 6 cases of primary gastric cancer, while WNT6 was not up-regulated in primary gastric cancer. Effects of inflammatory cytokines and Helicobacter pylori (H. pylori) on expression of WNT10A and WNT6 were next investigated. Interferon γ (IFNγ) failed to induce up-regulation of WNT10A and WNT6. Tumor necrosis factor α (TNFα) induced up-regulation of WNT10A in MKN45 cells. Up-regulation of WNT10A reached maximum at 6 h after TNFα treatment. H. pylori also induced up-regulation of WNT10A in MKN45 cells. These results strongly suggest that up-regulation of WNT10A induced by TNFα and H. pylori might play key roles in human gastric cancer through activation of WNT - β-catenin - TCF signaling pathway.

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Copy and paste a formatted citation
Spandidos Publications style
Kirikoshi H, Sekihara H and Katoh M: Up-regulation of WNT10A by tumor necrosis factor α and Helicobacter pylori in gastric cancer. Int J Oncol 19: 533-536, 2001.
APA
Kirikoshi, H., Sekihara, H., & Katoh, M. (2001). Up-regulation of WNT10A by tumor necrosis factor α and Helicobacter pylori in gastric cancer. International Journal of Oncology, 19, 533-536. https://doi.org/10.3892/ijo.19.3.533
MLA
Kirikoshi, H., Sekihara, H., Katoh, M."Up-regulation of WNT10A by tumor necrosis factor α and Helicobacter pylori in gastric cancer". International Journal of Oncology 19.3 (2001): 533-536.
Chicago
Kirikoshi, H., Sekihara, H., Katoh, M."Up-regulation of WNT10A by tumor necrosis factor α and Helicobacter pylori in gastric cancer". International Journal of Oncology 19, no. 3 (2001): 533-536. https://doi.org/10.3892/ijo.19.3.533
Copy and paste a formatted citation
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Spandidos Publications style
Kirikoshi H, Sekihara H and Katoh M: Up-regulation of WNT10A by tumor necrosis factor α and Helicobacter pylori in gastric cancer. Int J Oncol 19: 533-536, 2001.
APA
Kirikoshi, H., Sekihara, H., & Katoh, M. (2001). Up-regulation of WNT10A by tumor necrosis factor α and Helicobacter pylori in gastric cancer. International Journal of Oncology, 19, 533-536. https://doi.org/10.3892/ijo.19.3.533
MLA
Kirikoshi, H., Sekihara, H., Katoh, M."Up-regulation of WNT10A by tumor necrosis factor α and Helicobacter pylori in gastric cancer". International Journal of Oncology 19.3 (2001): 533-536.
Chicago
Kirikoshi, H., Sekihara, H., Katoh, M."Up-regulation of WNT10A by tumor necrosis factor α and Helicobacter pylori in gastric cancer". International Journal of Oncology 19, no. 3 (2001): 533-536. https://doi.org/10.3892/ijo.19.3.533
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