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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 2001 Volume 19 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2001 Volume 19 Issue 3

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Article

Effects of tetramethylpiperidine (TMP)-substituted phenazines on membrane stability and P-glycoprotein function

  • Authors:
    • C. Durandt
    • C. E.J. Van Rensburg

  • View Affiliations / Copyright

    Affiliations: Medical Research Council Unit for Inflammation and Immunity, Department of Immunology, Institute for Pathology, Faculty of Medicine, University of Pretoria, Pretoria, Republic of South Africa
  • Pages: 579-583
    |
    Published online on: September 1, 2001
       https://doi.org/10.3892/ijo.19.3.579
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Abstract

The lipophilicity and membrane-destabilizing activities of clofazimine and three tetramethyl-piperidine (TMP)-substituted phenazines were compared with the anti-tumor and multiple drug resistance (MDR) neutralizing potential of these agents using a P-glycoprotein (P-gp)-expressing small cell lung cancer cell line (H69/LX4). Partition coefficients were measured as an index of lipophilicity, while membrane-destabilizing potential was measured using a conventional hemolytic assay. The membrane-destabilizing potential of the TMP-substituted phenazines was found to correlate positively with the degree of lipophilicity, as well as with MDR reversal activity. The presence of a TMP group, as well as chlorine atoms on the phenyl and anilino rings of these agents contributed to the enhancement of anti-tumor activity by potentiating membrane-destabilizing activity. TMP-substituted phenazines may be useful in the design of novel anti-cancer and MDR reversal agents.

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Copy and paste a formatted citation
Spandidos Publications style
Durandt C and Van Rensburg CE: Effects of tetramethylpiperidine (TMP)-substituted phenazines on membrane stability and P-glycoprotein function. Int J Oncol 19: 579-583, 2001.
APA
Durandt, C., & Van Rensburg, C.E. (2001). Effects of tetramethylpiperidine (TMP)-substituted phenazines on membrane stability and P-glycoprotein function. International Journal of Oncology, 19, 579-583. https://doi.org/10.3892/ijo.19.3.579
MLA
Durandt, C., Van Rensburg, C. E."Effects of tetramethylpiperidine (TMP)-substituted phenazines on membrane stability and P-glycoprotein function". International Journal of Oncology 19.3 (2001): 579-583.
Chicago
Durandt, C., Van Rensburg, C. E."Effects of tetramethylpiperidine (TMP)-substituted phenazines on membrane stability and P-glycoprotein function". International Journal of Oncology 19, no. 3 (2001): 579-583. https://doi.org/10.3892/ijo.19.3.579
Copy and paste a formatted citation
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Spandidos Publications style
Durandt C and Van Rensburg CE: Effects of tetramethylpiperidine (TMP)-substituted phenazines on membrane stability and P-glycoprotein function. Int J Oncol 19: 579-583, 2001.
APA
Durandt, C., & Van Rensburg, C.E. (2001). Effects of tetramethylpiperidine (TMP)-substituted phenazines on membrane stability and P-glycoprotein function. International Journal of Oncology, 19, 579-583. https://doi.org/10.3892/ijo.19.3.579
MLA
Durandt, C., Van Rensburg, C. E."Effects of tetramethylpiperidine (TMP)-substituted phenazines on membrane stability and P-glycoprotein function". International Journal of Oncology 19.3 (2001): 579-583.
Chicago
Durandt, C., Van Rensburg, C. E."Effects of tetramethylpiperidine (TMP)-substituted phenazines on membrane stability and P-glycoprotein function". International Journal of Oncology 19, no. 3 (2001): 579-583. https://doi.org/10.3892/ijo.19.3.579
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