Effect of thermosensitive liposomal doxorubicin with hyperthermia on primary tumor and lung metastases in hamster osteosarcoma

  • Authors:
    • Shoji Shimose
    • Takashi Sugita
    • Yasuaki Nitta
    • Tadahiko Kubo
    • Yoshikazu Ikuta
    • Teruo Murakami
  • View Affiliations

  • Published online on: September 1, 2001     https://doi.org/10.3892/ijo.19.3.585
  • Pages: 585-589
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Abstract

We evaluated the effect of intravenous thermosensitive liposomal doxorubicin (TL-DOX) together with local hyperthermia on primary tumors in highly metastatic hamster osteosarcoma. This combination resulted in higher DOX concentrations in plasma, primary tumors and lungs than standard DOX under the same conditions. Tumor growth and lung metastasis were also inhibited more by TL-DOX and hyperthermia than by hyperthermia alone, DOX with or without hyperthermia, and TL-DOX without hyperthermia. In addition, gains in hamster body weight were not suppressed. These results suggest that the combination of TL-DOX and hyperthermia can control primary tumors and suppress lung metastasis in hamsters.

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September 2001
Volume 19 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Shimose S, Sugita T, Nitta Y, Kubo T, Ikuta Y and Murakami T: Effect of thermosensitive liposomal doxorubicin with hyperthermia on primary tumor and lung metastases in hamster osteosarcoma. Int J Oncol 19: 585-589, 2001.
APA
Shimose, S., Sugita, T., Nitta, Y., Kubo, T., Ikuta, Y., & Murakami, T. (2001). Effect of thermosensitive liposomal doxorubicin with hyperthermia on primary tumor and lung metastases in hamster osteosarcoma. International Journal of Oncology, 19, 585-589. https://doi.org/10.3892/ijo.19.3.585
MLA
Shimose, S., Sugita, T., Nitta, Y., Kubo, T., Ikuta, Y., Murakami, T."Effect of thermosensitive liposomal doxorubicin with hyperthermia on primary tumor and lung metastases in hamster osteosarcoma". International Journal of Oncology 19.3 (2001): 585-589.
Chicago
Shimose, S., Sugita, T., Nitta, Y., Kubo, T., Ikuta, Y., Murakami, T."Effect of thermosensitive liposomal doxorubicin with hyperthermia on primary tumor and lung metastases in hamster osteosarcoma". International Journal of Oncology 19, no. 3 (2001): 585-589. https://doi.org/10.3892/ijo.19.3.585