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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 2001 Volume 19 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2001 Volume 19 Issue 4

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Article

DNA amplification on chromosome 7q in squamous cell carcinoma of the tongue

  • Authors:
    • H. Steinhart
    • J. Bohlender
    • H. Iro
    • Volker Jung
    • J. Constantinidis
    • E. Gebhart
    • S. Pahl
    • S. Urbschat

  • View Affiliations / Copyright

    Affiliations: University of Erlangen-Nuremberg, D-91054 Erlangen, Germany
  • Pages: 851-855
    |
    Published online on: October 1, 2001
       https://doi.org/10.3892/ijo.19.4.851
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Abstract

Squamous cell carcinoma of the head and neck exhibit a highly variable picture of chromosomal aberrations. In the present study the clearly defined anatomical region of the tongue was analyzed for potentially specific patterns of chromosomal alterations. Fresh tumor samples from 18 patients afflicted by squamous cell carcinoma of the tongue constituted the clinical basis of the present investigation. The tumor samples were analyzed on the basis of comparative genomic hybridization (CGH), a molecular cytogenetic FISH-approach. Gains in DNA copy numbers were detected as the predominant imbalance on chromosomes 7q (9/18), 3q (48/18), 16p (7/18) and 20q (7/18). The regions of minimal overlap on these chromosomes were mapped to 7q11.2q11.3 and 3q26. A conspicuous finding was the frequent detection of amplifications in the 7q11 region. Gains in the 7q region have been rarely reported in CGH studies of tumors derived from different regions of the head and neck. Amplifications on 7q could thus be specifically linked with the tongue region and could correlate with specific clinical factors of this tumor entity.

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Copy and paste a formatted citation
Spandidos Publications style
Steinhart H, Bohlender J, Iro H, Jung V, Constantinidis J, Gebhart E, Pahl S and Urbschat S: DNA amplification on chromosome 7q in squamous cell carcinoma of the tongue. Int J Oncol 19: 851-855, 2001.
APA
Steinhart, H., Bohlender, J., Iro, H., Jung, V., Constantinidis, J., Gebhart, E. ... Urbschat, S. (2001). DNA amplification on chromosome 7q in squamous cell carcinoma of the tongue. International Journal of Oncology, 19, 851-855. https://doi.org/10.3892/ijo.19.4.851
MLA
Steinhart, H., Bohlender, J., Iro, H., Jung, V., Constantinidis, J., Gebhart, E., Pahl, S., Urbschat, S."DNA amplification on chromosome 7q in squamous cell carcinoma of the tongue". International Journal of Oncology 19.4 (2001): 851-855.
Chicago
Steinhart, H., Bohlender, J., Iro, H., Jung, V., Constantinidis, J., Gebhart, E., Pahl, S., Urbschat, S."DNA amplification on chromosome 7q in squamous cell carcinoma of the tongue". International Journal of Oncology 19, no. 4 (2001): 851-855. https://doi.org/10.3892/ijo.19.4.851
Copy and paste a formatted citation
x
Spandidos Publications style
Steinhart H, Bohlender J, Iro H, Jung V, Constantinidis J, Gebhart E, Pahl S and Urbschat S: DNA amplification on chromosome 7q in squamous cell carcinoma of the tongue. Int J Oncol 19: 851-855, 2001.
APA
Steinhart, H., Bohlender, J., Iro, H., Jung, V., Constantinidis, J., Gebhart, E. ... Urbschat, S. (2001). DNA amplification on chromosome 7q in squamous cell carcinoma of the tongue. International Journal of Oncology, 19, 851-855. https://doi.org/10.3892/ijo.19.4.851
MLA
Steinhart, H., Bohlender, J., Iro, H., Jung, V., Constantinidis, J., Gebhart, E., Pahl, S., Urbschat, S."DNA amplification on chromosome 7q in squamous cell carcinoma of the tongue". International Journal of Oncology 19.4 (2001): 851-855.
Chicago
Steinhart, H., Bohlender, J., Iro, H., Jung, V., Constantinidis, J., Gebhart, E., Pahl, S., Urbschat, S."DNA amplification on chromosome 7q in squamous cell carcinoma of the tongue". International Journal of Oncology 19, no. 4 (2001): 851-855. https://doi.org/10.3892/ijo.19.4.851
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