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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 2001 Volume 19 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November 2001 Volume 19 Issue 5

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Article

Potential of adenoviral p53 gene therapy and irradiation for the treatment of malignant gliomas

  • Authors:
    • In Ah Kim
    • Youn Ju Yang
    • Sei Chul Yoon
    • Ihl Bhong Choi
    • Chul Seung Kay
    • Hee Chung Kwon
    • Chang Min Kim
    • Young Ae Joe
    • Joon-Ki Kang
    • Yong Kil Hong

  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, The Catholic University of Korea, Seoul, Korea
  • Pages: 1041-1047
    |
    Published online on: November 1, 2001
       https://doi.org/10.3892/ijo.19.5.1041
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Abstract

We investigated the combined effects of p53 gene transfer and irradiation and its still unclear interaction mechanism in human gliomas. Four human glioma cell lines expressing mutant type p53 (U373 and A172) and wild-type p53 (D54MG and EFC-2) were transfected by adenoviral vectors bearing p53 gene at 50 multiplicity of infection. Two days after transfection, cells were irradiated (3, 6, and 9 Gy). The cytotoxicity was evaluated by clonogenic assay. The quantitative analysis of apoptosis and cell cycle analysis were performed using flow cytometry. Irradiation combined with adenoviral p53 transfection significantly increased cytotoxicity, which was additive in cell lines with wild-type p53 and more than additive in cell lines with mutant p53. The combination of two modalities increased the apoptotic population by 14% in A172 cells and 20% in D54 MG cells, which were the sum of apoptosis from each modality. Adenoviral p53 transfection increased the G1 phase fraction and concomitant decrease of radioresistant S phase fraction in A172 and D54MG cells. Our study demonstrated that p53 gene transfer combined with irradiation increased absolute cytotoxicity in human glioma cells used in this experiment. The interaction mechanism for increased cytotoxicity involved, in part, increased apoptosis and change of cell cycle profile.

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Copy and paste a formatted citation
Spandidos Publications style
Kim IA, Yang YJ, Yoon SC, Choi IB, Kay CS, Kwon HC, Kim CM, Joe YA, Kang J, Hong YK, Hong YK, et al: Potential of adenoviral p53 gene therapy and irradiation for the treatment of malignant gliomas. Int J Oncol 19: 1041-1047, 2001.
APA
Kim, I.A., Yang, Y.J., Yoon, S.C., Choi, I.B., Kay, C.S., Kwon, H.C. ... Hong, Y.K. (2001). Potential of adenoviral p53 gene therapy and irradiation for the treatment of malignant gliomas. International Journal of Oncology, 19, 1041-1047. https://doi.org/10.3892/ijo.19.5.1041
MLA
Kim, I. A., Yang, Y. J., Yoon, S. C., Choi, I. B., Kay, C. S., Kwon, H. C., Kim, C. M., Joe, Y. A., Kang, J., Hong, Y. K."Potential of adenoviral p53 gene therapy and irradiation for the treatment of malignant gliomas". International Journal of Oncology 19.5 (2001): 1041-1047.
Chicago
Kim, I. A., Yang, Y. J., Yoon, S. C., Choi, I. B., Kay, C. S., Kwon, H. C., Kim, C. M., Joe, Y. A., Kang, J., Hong, Y. K."Potential of adenoviral p53 gene therapy and irradiation for the treatment of malignant gliomas". International Journal of Oncology 19, no. 5 (2001): 1041-1047. https://doi.org/10.3892/ijo.19.5.1041
Copy and paste a formatted citation
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Spandidos Publications style
Kim IA, Yang YJ, Yoon SC, Choi IB, Kay CS, Kwon HC, Kim CM, Joe YA, Kang J, Hong YK, Hong YK, et al: Potential of adenoviral p53 gene therapy and irradiation for the treatment of malignant gliomas. Int J Oncol 19: 1041-1047, 2001.
APA
Kim, I.A., Yang, Y.J., Yoon, S.C., Choi, I.B., Kay, C.S., Kwon, H.C. ... Hong, Y.K. (2001). Potential of adenoviral p53 gene therapy and irradiation for the treatment of malignant gliomas. International Journal of Oncology, 19, 1041-1047. https://doi.org/10.3892/ijo.19.5.1041
MLA
Kim, I. A., Yang, Y. J., Yoon, S. C., Choi, I. B., Kay, C. S., Kwon, H. C., Kim, C. M., Joe, Y. A., Kang, J., Hong, Y. K."Potential of adenoviral p53 gene therapy and irradiation for the treatment of malignant gliomas". International Journal of Oncology 19.5 (2001): 1041-1047.
Chicago
Kim, I. A., Yang, Y. J., Yoon, S. C., Choi, I. B., Kay, C. S., Kwon, H. C., Kim, C. M., Joe, Y. A., Kang, J., Hong, Y. K."Potential of adenoviral p53 gene therapy and irradiation for the treatment of malignant gliomas". International Journal of Oncology 19, no. 5 (2001): 1041-1047. https://doi.org/10.3892/ijo.19.5.1041
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