Effect of platelet activating factor and butyrate on the expression of interleukin-2 receptor α in nasopharyngeal carcinoma cells

Tsai,Ming-Hsui; Chiou,Shiow-Her; Chow,Kuan-Chih

doi:10.3892/ijo.19.5.1049

November 2001 Volume 19 Issue 5

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November 2001 Volume 19 Issue 5

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Article

Effect of platelet activating factor and butyrate on the expression of interleukin-2 receptor α in nasopharyngeal carcinoma cells

Authors:
- Ming-Hsui Tsai
- Shiow-Her Chiou
- Kuan-Chih Chow
View Affiliations / Copyright

Affiliations: Department of Otolaryngology, China Medical College Hospital and Institute of Medical Research, China Medical College, Taichung, Taiwan
Pages: 1049-1055
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Published online on: November 1, 2001

https://doi.org/10.3892/ijo.19.5.1049
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Abstract

Serum level of soluble interleukin-2 receptor α (sIL-2Rα) has been shown to correlate with disease progression and prognosis of cancer patients. However, the available information about the source and the pathophysiological regulation of IL-2Rα in cancer cells is limited. This study addressed the questions of prognostic value and the source of sIL-2Rα in patients with nasopharyngeal carcinoma (NPC). Biological regulation of IL-2Rα was characterized in NPC cell lines. Serum sIL-2Rα levels of 113 NPC patients were measured by enzyme-linked immunosorbent assay (ELISA). Levels of sIL-2Rα in NPC patients were significantly higher than that in the healthy controls, and sIL-2Rα levels were correlated with disease progression and patient survival. IL-2Rα was identified in cancer cells by immunocytochemistry. In vitro, IL-2Rα expression was markedly increased following treatment with platelet activating factor and/or n-sodium butyrate. Increased secretion of IL-2Rα was also detected in the culture media. The secreted IL-2Rα could functionally bind IL-2. These results indicate that elevated sIL-2Rα was often detected in patients with advanced NPC. The elevated sIL-2Rα could be shed from NPC cells by a yet to be determined mechanism and IL-2Rα expression in NPC cells could be upregulated by platelet activating factor and butyrate.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Effect of platelet activating factor and butyrate on the expression of interleukin-2 receptor α in nasopharyngeal carcinoma cells

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Abstract

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