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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 2001 Volume 19 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November 2001 Volume 19 Issue 5

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Article

Unique action determinants of double acting topoisomerase inhibitor, TAS-103

  • Authors:
    • Ryo Okamoto
    • Hiroshi Takano
    • Takashi Sekikawa
    • Tomotaka Tanaka
    • Masahiro Toyada
    • Kei Ukon
    • Keiji Tanimoto
    • Tsutomu Kumazaki
    • Masahiko Nishiyama
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry and Biophysics, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
  • Pages: 921-927
    |
    Published online on: November 1, 2001
       https://doi.org/10.3892/ijo.19.5.921
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Abstract

O6-methylguanine-DNA methyltransferase (MGMT), γ-glutamylcysteine synthetase (γ-GCS), and glutathione (GSH) are found to participate in resistance to TAS-103, a topoisomerase I/II inhibitor. In 13 human cancer cell lines, MGMT expression correlated with IC50 for TAS-103, whereas γ-GCS expression inversely correlated with the IC50 value, suggesting MGMT may work to decrease TAS-103 activity but γ-GCS may increase it. A reduced γ-GCS and GSH, and an increased MGMT were associated with the development of resistance in A549 and DLD cells, and γ-GCS inhibition by buthionine sulphoximine increased the TAS-103 resistance, whereas MGMT inhibition by both O6-benzyl-guanine and MGMT-antisense transfection sensitized cells to TAS-103.

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Copy and paste a formatted citation
Spandidos Publications style
Okamoto R, Takano H, Sekikawa T, Tanaka T, Toyada M, Ukon K, Tanimoto K, Kumazaki T and Nishiyama M: Unique action determinants of double acting topoisomerase inhibitor, TAS-103. Int J Oncol 19: 921-927, 2001.
APA
Okamoto, R., Takano, H., Sekikawa, T., Tanaka, T., Toyada, M., Ukon, K. ... Nishiyama, M. (2001). Unique action determinants of double acting topoisomerase inhibitor, TAS-103. International Journal of Oncology, 19, 921-927. https://doi.org/10.3892/ijo.19.5.921
MLA
Okamoto, R., Takano, H., Sekikawa, T., Tanaka, T., Toyada, M., Ukon, K., Tanimoto, K., Kumazaki, T., Nishiyama, M."Unique action determinants of double acting topoisomerase inhibitor, TAS-103". International Journal of Oncology 19.5 (2001): 921-927.
Chicago
Okamoto, R., Takano, H., Sekikawa, T., Tanaka, T., Toyada, M., Ukon, K., Tanimoto, K., Kumazaki, T., Nishiyama, M."Unique action determinants of double acting topoisomerase inhibitor, TAS-103". International Journal of Oncology 19, no. 5 (2001): 921-927. https://doi.org/10.3892/ijo.19.5.921
Copy and paste a formatted citation
x
Spandidos Publications style
Okamoto R, Takano H, Sekikawa T, Tanaka T, Toyada M, Ukon K, Tanimoto K, Kumazaki T and Nishiyama M: Unique action determinants of double acting topoisomerase inhibitor, TAS-103. Int J Oncol 19: 921-927, 2001.
APA
Okamoto, R., Takano, H., Sekikawa, T., Tanaka, T., Toyada, M., Ukon, K. ... Nishiyama, M. (2001). Unique action determinants of double acting topoisomerase inhibitor, TAS-103. International Journal of Oncology, 19, 921-927. https://doi.org/10.3892/ijo.19.5.921
MLA
Okamoto, R., Takano, H., Sekikawa, T., Tanaka, T., Toyada, M., Ukon, K., Tanimoto, K., Kumazaki, T., Nishiyama, M."Unique action determinants of double acting topoisomerase inhibitor, TAS-103". International Journal of Oncology 19.5 (2001): 921-927.
Chicago
Okamoto, R., Takano, H., Sekikawa, T., Tanaka, T., Toyada, M., Ukon, K., Tanimoto, K., Kumazaki, T., Nishiyama, M."Unique action determinants of double acting topoisomerase inhibitor, TAS-103". International Journal of Oncology 19, no. 5 (2001): 921-927. https://doi.org/10.3892/ijo.19.5.921
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