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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2001 Volume 19 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2001 Volume 19 Issue 6

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Review

Methylation profiling of human cancers in blood: Molecular monitoring and prognostication (Review)

  • Authors:
    • Ivy H.N. Wong

  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, Faculty of Medicine, The University of Hong Kong, Hong Kong
  • Pages: 1319-1324
    |
    Published online on: December 1, 2001
       https://doi.org/10.3892/ijo.19.6.1319
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Abstract

Cancer is a polygenetic and polyepigenetic disease. Circulating tumor cells in peripheral blood have been demonstrated to reflect the biological characteristics of tumors including the potential of metastasis development and tumor recurrence. Aberrant promoter methylation has emergingly become a fundamental molecular abnormality leading to transcriptional silencing of tumor suppressor genes, DNA repair genes and metastasis inhibitor genes, and is linked to the predisposition of genetic alterations of other cancer-associated genes. This epigenetic inheritance has significant biological implications for cancer progression and metastasis formation. Of significance, DNA hypermethylation of multiple genes successfully detected in circulating tumor cells from cancer patients may prove valuable for disease monitoring. A number of epigenetic markers may feasibly enable the detection of circulating tumor cells from patients with different cancer types. The prognostic and therapeutic implications of aberrant DNA methylation could eventually bring forth improved outcome of cancer patients. A growing body of evidence and future advances in understanding cancer epigenetics may fuel us to monitor and treat cancers in alternative ways.

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Copy and paste a formatted citation
Spandidos Publications style
Wong IH: Methylation profiling of human cancers in blood: Molecular monitoring and prognostication (Review). Int J Oncol 19: 1319-1324, 2001.
APA
Wong, I.H. (2001). Methylation profiling of human cancers in blood: Molecular monitoring and prognostication (Review). International Journal of Oncology, 19, 1319-1324. https://doi.org/10.3892/ijo.19.6.1319
MLA
Wong, I. H."Methylation profiling of human cancers in blood: Molecular monitoring and prognostication (Review)". International Journal of Oncology 19.6 (2001): 1319-1324.
Chicago
Wong, I. H."Methylation profiling of human cancers in blood: Molecular monitoring and prognostication (Review)". International Journal of Oncology 19, no. 6 (2001): 1319-1324. https://doi.org/10.3892/ijo.19.6.1319
Copy and paste a formatted citation
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Spandidos Publications style
Wong IH: Methylation profiling of human cancers in blood: Molecular monitoring and prognostication (Review). Int J Oncol 19: 1319-1324, 2001.
APA
Wong, I.H. (2001). Methylation profiling of human cancers in blood: Molecular monitoring and prognostication (Review). International Journal of Oncology, 19, 1319-1324. https://doi.org/10.3892/ijo.19.6.1319
MLA
Wong, I. H."Methylation profiling of human cancers in blood: Molecular monitoring and prognostication (Review)". International Journal of Oncology 19.6 (2001): 1319-1324.
Chicago
Wong, I. H."Methylation profiling of human cancers in blood: Molecular monitoring and prognostication (Review)". International Journal of Oncology 19, no. 6 (2001): 1319-1324. https://doi.org/10.3892/ijo.19.6.1319
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