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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2001 Volume 19 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2001 Volume 19 Issue 6

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Article

Multiple lysosomal trafficking phenotypes in metastatic mouse mammary tumor cell lines

  • Authors:
    • Kai Tao
    • Jin Li
    • Jason Warner
    • Kathy MacLeod
    • Fred R. Miller
    • G. Gary Sahagian

  • View Affiliations / Copyright

    Affiliations: Department of Physiology, Tufts University School of Medicine, Boston, MA 02111, USA
  • Pages: 1333-1339
    |
    Published online on: December 1, 2001
       https://doi.org/10.3892/ijo.19.6.1333
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Abstract

Although altered synthesis and trafficking of lysosomal proteins and their receptors are associated with a wide range of human and rodent malignancies, the basis for their involvement remains obscure. Here we describe findings on a set of mouse mammary tumor cell lines that we are using as a model to study the role of these proteins in oncogenesis and tumor progression. Three distinct proteinase-secreting phenotypes were identified among the metastatic cell lines of the set. Two phenotypes displayed a high level of secretion of cathepsin L and the third was characterized by elevated secretion of matrix metalloproteinase 9 (MMP-9). The two cathepsin L-secreting phenotypes were distinct in that they displayed differences in cathepsin trafficking, expression of mannose 6-phosphate/insulin-like growth factor receptor and expression of proliferin, a mannose-phosphorylated angiogenic factor. Although cells representing all three phenotypes are capable of dissemination to distant organs when implanted into mouse mammary glands, only cells with the MMP-9 phenotype were found to be capable of direct intravasation. These findings indicate that multiple proteinase-secreting phenotypes can arise from the same tumor and suggest that cathepsin L and other lysosomal proteins may play a role in dissemination of tumor cells via the lymphatic system.

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Copy and paste a formatted citation
Spandidos Publications style
Tao K, Li J, Warner J, MacLeod K, Miller FR and Sahagian GG: Multiple lysosomal trafficking phenotypes in metastatic mouse mammary tumor cell lines. Int J Oncol 19: 1333-1339, 2001.
APA
Tao, K., Li, J., Warner, J., MacLeod, K., Miller, F.R., & Sahagian, G.G. (2001). Multiple lysosomal trafficking phenotypes in metastatic mouse mammary tumor cell lines. International Journal of Oncology, 19, 1333-1339. https://doi.org/10.3892/ijo.19.6.1333
MLA
Tao, K., Li, J., Warner, J., MacLeod, K., Miller, F. R., Sahagian, G. G."Multiple lysosomal trafficking phenotypes in metastatic mouse mammary tumor cell lines". International Journal of Oncology 19.6 (2001): 1333-1339.
Chicago
Tao, K., Li, J., Warner, J., MacLeod, K., Miller, F. R., Sahagian, G. G."Multiple lysosomal trafficking phenotypes in metastatic mouse mammary tumor cell lines". International Journal of Oncology 19, no. 6 (2001): 1333-1339. https://doi.org/10.3892/ijo.19.6.1333
Copy and paste a formatted citation
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Spandidos Publications style
Tao K, Li J, Warner J, MacLeod K, Miller FR and Sahagian GG: Multiple lysosomal trafficking phenotypes in metastatic mouse mammary tumor cell lines. Int J Oncol 19: 1333-1339, 2001.
APA
Tao, K., Li, J., Warner, J., MacLeod, K., Miller, F.R., & Sahagian, G.G. (2001). Multiple lysosomal trafficking phenotypes in metastatic mouse mammary tumor cell lines. International Journal of Oncology, 19, 1333-1339. https://doi.org/10.3892/ijo.19.6.1333
MLA
Tao, K., Li, J., Warner, J., MacLeod, K., Miller, F. R., Sahagian, G. G."Multiple lysosomal trafficking phenotypes in metastatic mouse mammary tumor cell lines". International Journal of Oncology 19.6 (2001): 1333-1339.
Chicago
Tao, K., Li, J., Warner, J., MacLeod, K., Miller, F. R., Sahagian, G. G."Multiple lysosomal trafficking phenotypes in metastatic mouse mammary tumor cell lines". International Journal of Oncology 19, no. 6 (2001): 1333-1339. https://doi.org/10.3892/ijo.19.6.1333
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