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EXPRESSION OF MULTIDRUG RESISTANCE (P-GLYCOPROTEIN) MDR1 AND MDR2 GENES IN HUMAN HEPATOCELLULAR CARCINOMAS AND LIVER METASTASES OF COLONIC TUMORS

  • Authors:
    • LD TEETER
    • HC HSU
    • SA CURLEY
    • MJ TONG
    • MT KUO

  • View Affiliations

  • Published online on: January 1, 1993     https://doi.org/10.3892/ijo.2.1.73
  • Pages: 73-80
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Abstract

Overexpression of P-glycoproteins (P-gp), encoded by multidrug resistance (MDR) genes is responsible for multidrug resistance in animal cells. We analyzed the expression of MDR genes in human hepatocellular carcinomas (HCC) and liver metastases of colon tumors by an RNase protection assay. Our results indicated that both genes were not consistently overexpressed in these tumors, whereas MDR2 is often underexpressed in the metastatic tumors. Invasion of colon tumors to livers decreased MDR1 expression. These data suggest differential regulation mechanisms for the expression of MDR1 and MDR2 genes in these tumors, and a complex drug-resistance mechanism for liver cancers.

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Journal Cover

January 1993
Volume 2 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Journal Metrics
  • Impact Factor: 5.2
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 11.4
  • CiteScore Rank: Q1: #40/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 1.125
  • SCImago Journal Rank (SJR): 1.105
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Spandidos Publications style
TEETER L, HSU H, CURLEY S, TONG M and KUO M: EXPRESSION OF MULTIDRUG RESISTANCE (P-GLYCOPROTEIN) MDR1 AND MDR2 GENES IN HUMAN HEPATOCELLULAR CARCINOMAS AND LIVER METASTASES OF COLONIC TUMORS. Int J Oncol 2: 73-80, 1993
APA
TEETER, L., HSU, H., CURLEY, S., TONG, M., & KUO, M. (1993). EXPRESSION OF MULTIDRUG RESISTANCE (P-GLYCOPROTEIN) MDR1 AND MDR2 GENES IN HUMAN HEPATOCELLULAR CARCINOMAS AND LIVER METASTASES OF COLONIC TUMORS. International Journal of Oncology, 2, 73-80. https://doi.org/10.3892/ijo.2.1.73
MLA
TEETER, L., HSU, H., CURLEY, S., TONG, M., KUO, M."EXPRESSION OF MULTIDRUG RESISTANCE (P-GLYCOPROTEIN) MDR1 AND MDR2 GENES IN HUMAN HEPATOCELLULAR CARCINOMAS AND LIVER METASTASES OF COLONIC TUMORS". International Journal of Oncology 2.1 (1993): 73-80.
Chicago
TEETER, L., HSU, H., CURLEY, S., TONG, M., KUO, M."EXPRESSION OF MULTIDRUG RESISTANCE (P-GLYCOPROTEIN) MDR1 AND MDR2 GENES IN HUMAN HEPATOCELLULAR CARCINOMAS AND LIVER METASTASES OF COLONIC TUMORS". International Journal of Oncology 2, no. 1 (1993): 73-80. https://doi.org/10.3892/ijo.2.1.73