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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 1993 Volume 2 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 1993 Volume 2 Issue 2

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SELECTIVE CYTOSTATIC ACTIVITY OF HEXADECYLPHOSPHOCHOLINE AGAINST TUMOR-CELLS INVITRO LEADS TO THE ESTABLISHMENT OF AN INVIVO SCREENING SYSTEM FOR PHOSPHOLIPID ANALOGS

  • Authors:
    • R VOEGELI
    • C ECHARTI
    • HR MAURER
    • J STEKAR
    • P HILGARD
    • C UNGER

  • View Affiliations / Copyright

    Affiliations: FREIEN UNIV BERLIN,INST PHARM,W-1000 BERLIN 41,GERMANY. UNIV GOTTINGEN,DEPT HEMATOL ONCOL,MED KLIN,W-3400 GOTTINGEN,GERMANY.
  • Pages: 161-164
    |
    Published online on: February 1, 1993
       https://doi.org/10.3892/ijo.2.2.161
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Abstract

Hexadecylphosphocholine (HPC, D-18506, INN: Miltefosine) was characterized in a clonogenic micro assay in vitro with respect to its cytotoxicity against a panel of human and murine tumor cell lines and murine bone marrow cultures (GM-CFC). The KB human epithelial carcinoma line was found to be more sensitive by at least one order of magnitude than the murine tumor cell lines which are in vivo insensitive to the drug. Xenotransplants of the KB cell line into nude mice were highly sensitive to HPC with optimal treatment resulting in total regression of the tumor. Twenty-seven structural analogues of HPC were tested in vivo in our normal screening system, the dimethylbenz(a)anthracene(DMBA)-induced mammary carcinoma of the rat, and against KB-xenotransplants. 88 % of the compounds rated identically in both models, no compound was classified falsely negative in the KB model. These results allow to adopt the KB-model, which is easier to perform, as a reliable primary screening system for phospholipid analogues without the risk of missing active compounds.

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Copy and paste a formatted citation
Spandidos Publications style
VOEGELI R, ECHARTI C, MAURER H, STEKAR J, HILGARD P and UNGER C: SELECTIVE CYTOSTATIC ACTIVITY OF HEXADECYLPHOSPHOCHOLINE AGAINST TUMOR-CELLS INVITRO LEADS TO THE ESTABLISHMENT OF AN INVIVO SCREENING SYSTEM FOR PHOSPHOLIPID ANALOGS. Int J Oncol 2: 161-164, 1993.
APA
VOEGELI, R., ECHARTI, C., MAURER, H., STEKAR, J., HILGARD, P., & UNGER, C. (1993). SELECTIVE CYTOSTATIC ACTIVITY OF HEXADECYLPHOSPHOCHOLINE AGAINST TUMOR-CELLS INVITRO LEADS TO THE ESTABLISHMENT OF AN INVIVO SCREENING SYSTEM FOR PHOSPHOLIPID ANALOGS. International Journal of Oncology, 2, 161-164. https://doi.org/10.3892/ijo.2.2.161
MLA
VOEGELI, R., ECHARTI, C., MAURER, H., STEKAR, J., HILGARD, P., UNGER, C."SELECTIVE CYTOSTATIC ACTIVITY OF HEXADECYLPHOSPHOCHOLINE AGAINST TUMOR-CELLS INVITRO LEADS TO THE ESTABLISHMENT OF AN INVIVO SCREENING SYSTEM FOR PHOSPHOLIPID ANALOGS". International Journal of Oncology 2.2 (1993): 161-164.
Chicago
VOEGELI, R., ECHARTI, C., MAURER, H., STEKAR, J., HILGARD, P., UNGER, C."SELECTIVE CYTOSTATIC ACTIVITY OF HEXADECYLPHOSPHOCHOLINE AGAINST TUMOR-CELLS INVITRO LEADS TO THE ESTABLISHMENT OF AN INVIVO SCREENING SYSTEM FOR PHOSPHOLIPID ANALOGS". International Journal of Oncology 2, no. 2 (1993): 161-164. https://doi.org/10.3892/ijo.2.2.161
Copy and paste a formatted citation
x
Spandidos Publications style
VOEGELI R, ECHARTI C, MAURER H, STEKAR J, HILGARD P and UNGER C: SELECTIVE CYTOSTATIC ACTIVITY OF HEXADECYLPHOSPHOCHOLINE AGAINST TUMOR-CELLS INVITRO LEADS TO THE ESTABLISHMENT OF AN INVIVO SCREENING SYSTEM FOR PHOSPHOLIPID ANALOGS. Int J Oncol 2: 161-164, 1993.
APA
VOEGELI, R., ECHARTI, C., MAURER, H., STEKAR, J., HILGARD, P., & UNGER, C. (1993). SELECTIVE CYTOSTATIC ACTIVITY OF HEXADECYLPHOSPHOCHOLINE AGAINST TUMOR-CELLS INVITRO LEADS TO THE ESTABLISHMENT OF AN INVIVO SCREENING SYSTEM FOR PHOSPHOLIPID ANALOGS. International Journal of Oncology, 2, 161-164. https://doi.org/10.3892/ijo.2.2.161
MLA
VOEGELI, R., ECHARTI, C., MAURER, H., STEKAR, J., HILGARD, P., UNGER, C."SELECTIVE CYTOSTATIC ACTIVITY OF HEXADECYLPHOSPHOCHOLINE AGAINST TUMOR-CELLS INVITRO LEADS TO THE ESTABLISHMENT OF AN INVIVO SCREENING SYSTEM FOR PHOSPHOLIPID ANALOGS". International Journal of Oncology 2.2 (1993): 161-164.
Chicago
VOEGELI, R., ECHARTI, C., MAURER, H., STEKAR, J., HILGARD, P., UNGER, C."SELECTIVE CYTOSTATIC ACTIVITY OF HEXADECYLPHOSPHOCHOLINE AGAINST TUMOR-CELLS INVITRO LEADS TO THE ESTABLISHMENT OF AN INVIVO SCREENING SYSTEM FOR PHOSPHOLIPID ANALOGS". International Journal of Oncology 2, no. 2 (1993): 161-164. https://doi.org/10.3892/ijo.2.2.161
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