HUMAN CD4+ CD45RA+ LYMPHOCYTES-T CAN BE STIMULATED BY CROCIDOLITE, ANTHOPHYLLITE AND AMOSITE ASBESTOS INVITRO
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- Published online on: February 1, 1993 https://doi.org/10.3892/ijo.2.2.209
- Pages: 209-212
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Abstract
Crocidolite, anthophyllite and amosite asbestos stimulate T lymphocyte subsets. Cell surface CD4 or CD45RA expression in peripheral blood mononuclear cells (PBMC) was downregulated temporarily after incubation with asbestos in vitro. The percentage of CD4+ CD45RA+ cells significantly decreased 12 h after incubation with asbestos, suggesting activation of the cells. An early increase in the intracellular Ca++ level was also indicative of activation. An elevated Ca++ level was observed after incubation in both PBMC and purified T cell fractions.