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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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March 1993 Volume 2 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 1993 Volume 2 Issue 3

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Article

EFFECTS OF ETHINYL ESTRADIOL AND EPIDERMAL GROWTH-FACTOR ON DNA-SYNTHESIS IN HUMAN CULTURED-HEPATOCYTES

  • Authors:
    • M GHIA
    • A ALLAVENA
    • E MERETO

  • View Affiliations / Copyright

    Affiliations: Affliations not specified
  • Pages: 381-384
    |
    Published online on: March 1, 1993
       https://doi.org/10.3892/ijo.2.3.381
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Abstract

It has been demonstrated that the liver tumor promoter ethinyl estradiol (EE) potentiates the DNA synthetic response of cultured rat hepatocytes to epidermal growth factor (EGF), probably acting as a comitogen with a growth factor of the EGF/TGF family. The present study investigated the effects of EE and EGF on DNA synthesis in cultures of rat and human hepatocytes obtained from 5 female donors. The cultures were given the following treatments: a. 15 muM EE for 30 h; b. 25 ng/ml of EGF for 12 h; c. combination of treatments a and b. The results obtained in rat hepatocytes confirm that EE potentiates the.DNA synthetic response to EGF, as evaluated by the labelling index. As to human hepatocytes, in only one case the response to EGF produced a significant increase of DNA synthesis and the EE pretreatment did not potentiate this effect. The results of this study indicate that, in contrast to the response observed in rat hepatocytes, EE does not seem to affect the DNA synthesis in primary cultures of human hepatocytes, and the association EE+EGF does not produce any synergic effect.

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Copy and paste a formatted citation
Spandidos Publications style
GHIA M, ALLAVENA A and MERETO E: EFFECTS OF ETHINYL ESTRADIOL AND EPIDERMAL GROWTH-FACTOR ON DNA-SYNTHESIS IN HUMAN CULTURED-HEPATOCYTES. Int J Oncol 2: 381-384, 1993.
APA
GHIA, M., ALLAVENA, A., & MERETO, E. (1993). EFFECTS OF ETHINYL ESTRADIOL AND EPIDERMAL GROWTH-FACTOR ON DNA-SYNTHESIS IN HUMAN CULTURED-HEPATOCYTES. International Journal of Oncology, 2, 381-384. https://doi.org/10.3892/ijo.2.3.381
MLA
GHIA, M., ALLAVENA, A., MERETO, E."EFFECTS OF ETHINYL ESTRADIOL AND EPIDERMAL GROWTH-FACTOR ON DNA-SYNTHESIS IN HUMAN CULTURED-HEPATOCYTES". International Journal of Oncology 2.3 (1993): 381-384.
Chicago
GHIA, M., ALLAVENA, A., MERETO, E."EFFECTS OF ETHINYL ESTRADIOL AND EPIDERMAL GROWTH-FACTOR ON DNA-SYNTHESIS IN HUMAN CULTURED-HEPATOCYTES". International Journal of Oncology 2, no. 3 (1993): 381-384. https://doi.org/10.3892/ijo.2.3.381
Copy and paste a formatted citation
x
Spandidos Publications style
GHIA M, ALLAVENA A and MERETO E: EFFECTS OF ETHINYL ESTRADIOL AND EPIDERMAL GROWTH-FACTOR ON DNA-SYNTHESIS IN HUMAN CULTURED-HEPATOCYTES. Int J Oncol 2: 381-384, 1993.
APA
GHIA, M., ALLAVENA, A., & MERETO, E. (1993). EFFECTS OF ETHINYL ESTRADIOL AND EPIDERMAL GROWTH-FACTOR ON DNA-SYNTHESIS IN HUMAN CULTURED-HEPATOCYTES. International Journal of Oncology, 2, 381-384. https://doi.org/10.3892/ijo.2.3.381
MLA
GHIA, M., ALLAVENA, A., MERETO, E."EFFECTS OF ETHINYL ESTRADIOL AND EPIDERMAL GROWTH-FACTOR ON DNA-SYNTHESIS IN HUMAN CULTURED-HEPATOCYTES". International Journal of Oncology 2.3 (1993): 381-384.
Chicago
GHIA, M., ALLAVENA, A., MERETO, E."EFFECTS OF ETHINYL ESTRADIOL AND EPIDERMAL GROWTH-FACTOR ON DNA-SYNTHESIS IN HUMAN CULTURED-HEPATOCYTES". International Journal of Oncology 2, no. 3 (1993): 381-384. https://doi.org/10.3892/ijo.2.3.381
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