A COMPARATIVE-ANALYSIS OF THE ACTIVITY OF RETINOIC ACID AND CYCLIC-AMP IN THE INDUCTION OF DIFFERENTIATION OF EMBRYONAL CARCINOMA-CELLS

  • Authors:
    • J DECKERT
    • J DIETRICH
    • PJ MCCORMICK
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  • Published online on: March 1, 1993     https://doi.org/10.3892/ijo.2.3.403
  • Pages: 403-412
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Abstract

Retinoic acid (RA) and/or cAMP elevating agents have been shown to promote differentiation of embryonal carcinoma (EC) cells. In this report we examine the response of different EC cell lines to different combinations of RA and cAMP elevating reagents. The degree of differentiation was measured via mRNA levels of stage specific markers: Endo A, collagen IV and tissue plasminogen activator. We show that complete differentiation cannot be achieved with cAMP elevating agents alone. Furthermore, the results obtained with each cell line are quite distinct and the degree of differentiation differs with the type of cAMP elevating agent used and the marker examined.

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March 1993
Volume 2 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
DECKERT J, DIETRICH J and MCCORMICK P: A COMPARATIVE-ANALYSIS OF THE ACTIVITY OF RETINOIC ACID AND CYCLIC-AMP IN THE INDUCTION OF DIFFERENTIATION OF EMBRYONAL CARCINOMA-CELLS. Int J Oncol 2: 403-412, 1993
APA
DECKERT, J., DIETRICH, J., & MCCORMICK, P. (1993). A COMPARATIVE-ANALYSIS OF THE ACTIVITY OF RETINOIC ACID AND CYCLIC-AMP IN THE INDUCTION OF DIFFERENTIATION OF EMBRYONAL CARCINOMA-CELLS. International Journal of Oncology, 2, 403-412. https://doi.org/10.3892/ijo.2.3.403
MLA
DECKERT, J., DIETRICH, J., MCCORMICK, P."A COMPARATIVE-ANALYSIS OF THE ACTIVITY OF RETINOIC ACID AND CYCLIC-AMP IN THE INDUCTION OF DIFFERENTIATION OF EMBRYONAL CARCINOMA-CELLS". International Journal of Oncology 2.3 (1993): 403-412.
Chicago
DECKERT, J., DIETRICH, J., MCCORMICK, P."A COMPARATIVE-ANALYSIS OF THE ACTIVITY OF RETINOIC ACID AND CYCLIC-AMP IN THE INDUCTION OF DIFFERENTIATION OF EMBRYONAL CARCINOMA-CELLS". International Journal of Oncology 2, no. 3 (1993): 403-412. https://doi.org/10.3892/ijo.2.3.403