THE COMPLEMENTARY ROLES OF SURFACE-IMMUNOGLOBULIN CLONALITY AND FLUORESCENCE INTENSITY, MOUSE ROSETTES, AND CD5 IN THE DIAGNOSIS OF B-CHRONIC LYMPHOCYTIC-LEUKEMIA

  • Authors:
    • A BATATA
    • B SHEN
    • B YANES
    • GL NICHOLSON
    • D HINES
    • JC CHANG
    • HM GROSS
    • M LLENADOLEE
    • S MERLE
  • View Affiliations

  • Published online on: March 1, 1993     https://doi.org/10.3892/ijo.2.3.425
  • Pages: 425-430
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Abstract

Peripheral blood from 77 cases of B-CLL was analyzed to evaluate the diagnostic value of SIg clonality and fluorescence intensity, mouse rosettes (MR), and CD5. Monoclonal SIg (L-chain restriction or H-chain restriction or both) was detected in 69 cases (89.61%), with weak fluorescence (mean channel number on flow cytometry <200) in 65 (94.2%); MR was positive in 66 (85.71%); CD5 positive in 64 (83.12%). The association of SIg intensity, MR, and CD5 was as follows: weak SIg/MR+/CD5+, 41 cases (53.25%); weak SIg/MR+/CD5-, 13 (16.88%); weak SIg/MR-/CD5+, 11 (14.29%); strong SIg/MR+/CD5+, 4 (5.19%); and undetected SIg/MR+/CD5+, 8 (10.39%). Thus, by performing the three markers and accepting either two or three positive results (weak SIg, MR+, CD5+) as sufficient for diagnosis, all 77 cases (100%) were diagnosed. The study demonstrated the complementary roles between L- and H- chains, and between SIg intensity, MR, and CD5 in immunophenotyping CLL.

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March 1993
Volume 2 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
BATATA A, SHEN B, YANES B, NICHOLSON G, HINES D, CHANG J, GROSS H, LLENADOLEE M and MERLE S: THE COMPLEMENTARY ROLES OF SURFACE-IMMUNOGLOBULIN CLONALITY AND FLUORESCENCE INTENSITY, MOUSE ROSETTES, AND CD5 IN THE DIAGNOSIS OF B-CHRONIC LYMPHOCYTIC-LEUKEMIA. Int J Oncol 2: 425-430, 1993
APA
BATATA, A., SHEN, B., YANES, B., NICHOLSON, G., HINES, D., CHANG, J. ... MERLE, S. (1993). THE COMPLEMENTARY ROLES OF SURFACE-IMMUNOGLOBULIN CLONALITY AND FLUORESCENCE INTENSITY, MOUSE ROSETTES, AND CD5 IN THE DIAGNOSIS OF B-CHRONIC LYMPHOCYTIC-LEUKEMIA. International Journal of Oncology, 2, 425-430. https://doi.org/10.3892/ijo.2.3.425
MLA
BATATA, A., SHEN, B., YANES, B., NICHOLSON, G., HINES, D., CHANG, J., GROSS, H., LLENADOLEE, M., MERLE, S."THE COMPLEMENTARY ROLES OF SURFACE-IMMUNOGLOBULIN CLONALITY AND FLUORESCENCE INTENSITY, MOUSE ROSETTES, AND CD5 IN THE DIAGNOSIS OF B-CHRONIC LYMPHOCYTIC-LEUKEMIA". International Journal of Oncology 2.3 (1993): 425-430.
Chicago
BATATA, A., SHEN, B., YANES, B., NICHOLSON, G., HINES, D., CHANG, J., GROSS, H., LLENADOLEE, M., MERLE, S."THE COMPLEMENTARY ROLES OF SURFACE-IMMUNOGLOBULIN CLONALITY AND FLUORESCENCE INTENSITY, MOUSE ROSETTES, AND CD5 IN THE DIAGNOSIS OF B-CHRONIC LYMPHOCYTIC-LEUKEMIA". International Journal of Oncology 2, no. 3 (1993): 425-430. https://doi.org/10.3892/ijo.2.3.425