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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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March 1993 Volume 2 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 1993 Volume 2 Issue 3

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COMBINED CYTOSINE-ARABINOSIDE PLUS INTERFERON-ALPHA .1. INTERFERON-ALPHA POTENTIATES THE EFFECT OF CYTOSINE-ARABINOSIDE IN HL-60 CELLS BY STIMULATION OF APOPTOSIS

  • Authors:
    • WR BEZWODA
    • N MANSOOR
    • L SEYMOUR

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    Affiliations: Affliations not specified
  • Pages: 463-467
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    Published online on: March 1, 1993
       https://doi.org/10.3892/ijo.2.3.463
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Abstract

Incubation of HL 60 human leukemia cells with cytosine arabinoside resulted in a dose and time dependant increase of cytotoxicity. The characteristics of the mechanism of cytotoxicity were shown to correspond to those of apoptotic cell death. Addition of interferon alpha in amounts as low as 10 u/ml potentiated the apoptosis inducing effect of cytosine arabinoside and moreover prevented recovery from sublethal toxicity after short duration exposure to the latter drug. The role of apoptosis as a mechanism for the lethal effects of certain cytotoxic agents is discussed. Perturbations of a number of different metabolic pathways appear to be able to trigger apoptosis-like cell death depending on, among other factors, cell lineage. While the HL 60 in vitro model may be particularly sensitive to apoptotic cell death by virtue of increased c-myc expression this propensity may well make it a suitable model for the development of clinical treatment regimens for patients with a number of hematologic malignancies which are characterized by increased c-myc expression in vivo.

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Copy and paste a formatted citation
Spandidos Publications style
BEZWODA W, MANSOOR N and SEYMOUR L: COMBINED CYTOSINE-ARABINOSIDE PLUS INTERFERON-ALPHA .1. INTERFERON-ALPHA POTENTIATES THE EFFECT OF CYTOSINE-ARABINOSIDE IN HL-60 CELLS BY STIMULATION OF APOPTOSIS. Int J Oncol 2: 463-467, 1993.
APA
BEZWODA, W., MANSOOR, N., & SEYMOUR, L. (1993). COMBINED CYTOSINE-ARABINOSIDE PLUS INTERFERON-ALPHA .1. INTERFERON-ALPHA POTENTIATES THE EFFECT OF CYTOSINE-ARABINOSIDE IN HL-60 CELLS BY STIMULATION OF APOPTOSIS. International Journal of Oncology, 2, 463-467. https://doi.org/10.3892/ijo.2.3.463
MLA
BEZWODA, W., MANSOOR, N., SEYMOUR, L."COMBINED CYTOSINE-ARABINOSIDE PLUS INTERFERON-ALPHA .1. INTERFERON-ALPHA POTENTIATES THE EFFECT OF CYTOSINE-ARABINOSIDE IN HL-60 CELLS BY STIMULATION OF APOPTOSIS". International Journal of Oncology 2.3 (1993): 463-467.
Chicago
BEZWODA, W., MANSOOR, N., SEYMOUR, L."COMBINED CYTOSINE-ARABINOSIDE PLUS INTERFERON-ALPHA .1. INTERFERON-ALPHA POTENTIATES THE EFFECT OF CYTOSINE-ARABINOSIDE IN HL-60 CELLS BY STIMULATION OF APOPTOSIS". International Journal of Oncology 2, no. 3 (1993): 463-467. https://doi.org/10.3892/ijo.2.3.463
Copy and paste a formatted citation
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Spandidos Publications style
BEZWODA W, MANSOOR N and SEYMOUR L: COMBINED CYTOSINE-ARABINOSIDE PLUS INTERFERON-ALPHA .1. INTERFERON-ALPHA POTENTIATES THE EFFECT OF CYTOSINE-ARABINOSIDE IN HL-60 CELLS BY STIMULATION OF APOPTOSIS. Int J Oncol 2: 463-467, 1993.
APA
BEZWODA, W., MANSOOR, N., & SEYMOUR, L. (1993). COMBINED CYTOSINE-ARABINOSIDE PLUS INTERFERON-ALPHA .1. INTERFERON-ALPHA POTENTIATES THE EFFECT OF CYTOSINE-ARABINOSIDE IN HL-60 CELLS BY STIMULATION OF APOPTOSIS. International Journal of Oncology, 2, 463-467. https://doi.org/10.3892/ijo.2.3.463
MLA
BEZWODA, W., MANSOOR, N., SEYMOUR, L."COMBINED CYTOSINE-ARABINOSIDE PLUS INTERFERON-ALPHA .1. INTERFERON-ALPHA POTENTIATES THE EFFECT OF CYTOSINE-ARABINOSIDE IN HL-60 CELLS BY STIMULATION OF APOPTOSIS". International Journal of Oncology 2.3 (1993): 463-467.
Chicago
BEZWODA, W., MANSOOR, N., SEYMOUR, L."COMBINED CYTOSINE-ARABINOSIDE PLUS INTERFERON-ALPHA .1. INTERFERON-ALPHA POTENTIATES THE EFFECT OF CYTOSINE-ARABINOSIDE IN HL-60 CELLS BY STIMULATION OF APOPTOSIS". International Journal of Oncology 2, no. 3 (1993): 463-467. https://doi.org/10.3892/ijo.2.3.463
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